2-((2,3-bis((9Z,12Z)-octadec-9,12-dien-1-yloxy)propyl)disulfanyl)-N,N-dimethylethanamine | 1415795-37-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-((2,3-bis((9Z,12Z)-octadec-9,12-dien-1-yloxy)propyl)disulfanyl)-N,N-dimethylethanamine
• 英文别名: 2-[2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propyldisulfanyl]-N,N-dimethylethanamine
• CAS: 1415795-37-7
• 化学式: C₄₃H₈₁NO₂S₂
• 分子量: 708.254
• InChiKey: DETCDJMMODGQRP-KWXKLSQISA-N

物化性质

• 沸点：
  717.4±60.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  48
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  72.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)propane-1-thiol 在 三乙胺 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 32.0h， 生成 2-((2,3-bis((9Z,12Z)-octadec-9,12-dien-1-yloxy)propyl)disulfanyl)-N,N-dimethylethanamine
  参考文献：
  名称：

  [EN] CLEAVABLE LIPIDS
  [FR] LIPIDES CLIVABLES

  摘要：

  公开号：

  WO2012170889A8

文献信息

• NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF
  申请人：Translate Bio, Inc.

  公开号：EP3536787A1

  公开（公告）日：2019-09-11

  The invention provides, among other things, methods of stabilizing mRNA and nuclease resistant mRNA prepared in accordance with such methods. In certain embodiments, the nuclease resistant mRNA encodes a functional protein, such as enzyme, and is characterized by its resistance to nuclease digestion, increased half-life and/or its ability to produce increased amounts of the functional protein (e.g., enzyme) encoded thereby.

  除其他外，本发明提供了稳定 mRNA 的方法和根据这些方法制备的抗核酸酶 mRNA。在某些实施方案中，抗核酸酶 mRNA 编码功能蛋白（如酶），其特点是抗核酸酶消化、半衰期延长和/或能够产生更多的功能蛋白（如酶）。
• LIPIDIC NANOPARTICLES FOR MRNA DELIVERY IN THE LUNGS
  申请人：Translate Bio, Inc.

  公开号：EP3628335A1

  公开（公告）日：2020-04-01

  Disclosed herein are compositions for use in am method of treating a disease in a subject, wherein the disease is due to a deficiency of a pulmonary surfactant-associated protein. The composition comprises mRNAs encoding the pulmonary surfactant-associated protein and a lipid nanoparticle that comprises cationic lipids, anionic lipids and PEG-modified lipids. The composition is to be administered via the pulmonary route.

  本文公开了用于治疗受试者疾病的方法的组合物，其中疾病是由于肺表面活性物质相关蛋白的缺乏引起的。组合物包括编码肺表面活性物质相关蛋白的 mRNA 和脂质纳米颗粒，脂质纳米颗粒包括阳离子脂质、阴离子脂质和 PEG 改性脂质。该组合物通过肺部途径给药。
• Lipid-derived neutral nanoparticles
  申请人：TRANSLATE BIO, INC.

  公开号：US10137086B2

  公开（公告）日：2018-11-27

  Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

  本文公开了新型脂质和使用此类化合物制备的脂质体组合物，以及中和或以其他方式修饰此类脂质体组合物的相关方法。例如，本文所述的脂质可用作脂质体载体，以促进将封装的多核苷酸递送到靶细胞并随后转染这些靶细胞。在某些实施方案中，可对组成脂质体递送载体的一种或多种化合物进行中和或进一步修饰，从而改变脂质体递送载体的性质。
• Synergistic enhancement of the delivery of nucleic acids via blended formulations
  申请人：TRANSLATE BIO, INC.

  公开号：US10130649B2

  公开（公告）日：2018-11-20

  Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.

  本文公开了包含脂质纳米颗粒 "混合物 "的药物组合物，以及使用此类混合物向一个或多个靶细胞、组织或器官递送多核苷酸的相关方法。 混合组合物的一般特征是能够有效地将多核苷酸递送至靶细胞，并能增强靶细胞对此类多核苷酸的表达和功能蛋白质的产生。
• Lipid nanoparticle compositions and methods for MRNA delivery
  申请人：Translate Bio, Inc.

  公开号：US10238754B2

  公开（公告）日：2019-03-26

  Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

  本文公开了用于调节靶细胞中蛋白质生产的组合物和方法。本文公开的组合物和方法能够改善与蛋白质或酶缺乏有关的疾病。