(16-bromohexadecyloxy)-t-butyl-dimethyl-silane | 909280-05-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (16-bromohexadecyloxy)-t-butyl-dimethyl-silane
• 英文别名: (16-Bromohexadecyloxy)-t-butyldimethylsilane；16-bromohexadecoxy-tert-butyl-dimethylsilane
• CAS: 909280-05-3
• 化学式: C₂₂H₄₇BrOSi
• 分子量: 435.604
• InChiKey: RATFFMPTLHBSGG-UHFFFAOYSA-N

物化性质

• 沸点：
  432.0±18.0 °C(Predicted)
• 密度：
  0.974±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.86
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (16-bromohexadecyloxy)-t-butyl-dimethyl-silane 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 16-(2,5-dimethoxyphenylamino)hexadecan-1-ol
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027
• 作为产物：
  描述：

  氧杂环十七烷-2-酮 在 咪唑 、 lithium aluminium tetrahydride 、 氢溴酸 作用下， 以 二氯甲烷 、 环己烷 为溶剂， 反应 10.0h， 生成 (16-bromohexadecyloxy)-t-butyl-dimethyl-silane
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027

文献信息

• Hydroquinone Long-Chain Derivative and/or Phenoxy Long-Chain Derivative and Pharmaceutical Comprising Same
  申请人：Luu Bang

  公开号：US20090036542A1

  公开（公告）日：2009-02-05

  The present invention provides compounds represented by formula (1) shown below: (wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R 6 , R 7 , R 8 , R 9 , and R 10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供以下式子（1）所示的化合物：（其中R1、R2、R3、R4和R5分别从氢原子、甲基基团、乙酰基团、羟基团和烷氧基中各自选择；X代表烷基或烯基）；以及以下式子（2）所示的化合物：（其中R6、R7、R8、R9和R10分别从氢原子、烷基、乙酰基团、羟基团和烷氧基中各自选择；A代表氧原子或NH，m为0或1；Y代表烷基或烯基，Z代表氢原子或羟基）。本发明的化合物对于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丧失引起的脑功能障碍、运动功能障碍或尿功能障碍是有用的。
• Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same
  申请人：Meiji Dairies Corporation

  公开号：US07893304B2

  公开（公告）日：2011-02-22

  The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供了化合物，用于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丢失引起的脑功能障碍、运动功能障碍或泌尿功能障碍。
• EP1854777
  申请人：——

  公开号：——

  公开（公告）日：——
• <i>o</i>-Phenylene Octamers as Surface Modifiers for Homeotropic Columnar Ordering of Discotic Liquid Crystals
  作者：Takashi Kajitani、Yuki Suna、Atsuko Kosaka、Terutsune Osawa、Shigenori Fujikawa、Masaki Takata、Takanori Fukushima、Takuzo Aida

  DOI：10.1021/ja4087853

  日期：2013.10.2

  Large area homeotropic columnar ordering of pi-conjugated discotic liquid crystals (LCs) is crucial for certain device applications but generally hard to achieve. Here we report polymeric p-phenylene octamer poly-1 and its monomer 1 as the first surface modifiers for homeotropic columnar order of a variety of discotic LCs up to a macroscopic length scale. Their octameric o-phenylene parts are known to fold helically into a cylinder that is reminiscent of a pi-stacked column of discotic LCs. Through-view X-ray diffraction patterns of 1 suggested that this molecule adheres to the glass substrate and directs its cylindrical axis perpendicular to the glass surface. This face on orientation likely nucleates the homeotropic columnar order of discotic LC materials.
• Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth
  作者：Mazen Hanbali、Dominique Bagnard、Bang Luu

  DOI：10.1016/j.bmcl.2006.05.027

  日期：2006.8

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.