[N-[3-hydroxymethylpiperidino]]-1phenylcyclohexane | 106339-31-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [N-[3-hydroxymethylpiperidino]]-1phenylcyclohexane
• 英文别名: [1-(1-Phenylcyclohexyl)piperidin-3-yl]methanol
• CAS: 106339-31-5
• 化学式: C₁₈H₂₇NO
• 分子量: 273.418
• InChiKey: PWFQWGXFDLUUMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [N-[3-hydroxymethylpiperidino]]-1phenylcyclohexane 生成 [1-(1-phenylcyclohexyl)piperidin-3-yl]methyl acetate
  参考文献：
  名称：

  KAMENKA, JEAN-MARC;PRIVAT, ALAIN;CHICHEPORTICHE, ROBERT RUBIN;ROUDOUIN, G+

  摘要：

  DOI：
• 作为产物：
  描述：

  1-[1-(3-hydroxymethyl-piperidino)-cyclohexan-1-yl]-carbonitrile 生成 [N-[3-hydroxymethylpiperidino]]-1phenylcyclohexane
  参考文献：
  名称：

  KAMENKA, JEAN-MARC;PRIVAT, ALAIN;CHICHEPORTICHE, ROBERT RUBIN;ROUDOUIN, G+

  摘要：

  DOI：

文献信息

• Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
  申请人：ABBOTT LABORATORIES

  公开号：EP0459387A2

  公开（公告）日：1991-12-04

  The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them, and a reagent kit containing them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及苯环利定和苯环利定衍生物的荧光偏振测定法、制备和进行这种测定法所需的各种成分以及制造这些成分的方法。具体而言，本发明公开了示踪剂、免疫原和抗体，以及制造它们的方法和含有它们的试剂盒。示踪剂和免疫原由取代的苯环利定化合物制成。示踪剂中含有荧光素分子，而免疫原中含有聚氨基酸分子。检测方法是测量通过含有抗血清和示踪剂的样品的平面偏振光的偏振保留程度。
• KAMENKA, JEAN-MARC;PRIVAT, ALAIN;CHICHEPORTICHE, ROBERT RUBIN;ROUDOUIN, G+
  作者：KAMENKA, JEAN-MARC、PRIVAT, ALAIN、CHICHEPORTICHE, ROBERT RUBIN、ROUDOUIN, G+

  DOI：——

  日期：——
• US5155212A
  申请人：——

  公开号：US5155212A

  公开（公告）日：1992-10-13
• US5407834A
  申请人：——

  公开号：US5407834A

  公开（公告）日：1995-04-18