2,5-Bis-(3,4-dimethoxy-phenyl)-furan | 4650-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-Bis-(3,4-dimethoxy-phenyl)-furan
• 英文别名: 2,5-bis(3,4-dimethoxyphenyl)furan
• CAS: 4650-69-5
• 化学式: C₂₀H₂₀O₅
• 分子量: 340.376
• InChiKey: ZESHRVUYCRWWFA-UHFFFAOYSA-N

物化性质

• 熔点：
  154-155 °C
• 沸点：
  443.2±45.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,5-Bis-(3,4-dimethoxy-phenyl)-furan 在 乙醇 、 镍 作用下， 生成 1,1'-(1,4-丁烷二基)二(3,4-二甲氧基苯)
  参考文献：
  名称：

  Traverso, Gazzetta Chimica Italiana, 1959, vol. 89, p. 1818,1823

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(3,4-dimethoxyphenyl)prop-2-en-1-one 在 ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide 、 对甲苯磺酸 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 2,5-Bis-(3,4-dimethoxy-phenyl)-furan
  参考文献：
  名称：

  Substituted furans as inhibitors of the PDE4 enzyme

  摘要：

  The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00742-2

文献信息

• Synthesis and evaluation of cytotoxic activity of arylfurans
  作者：Renata B. de Oliveira、Elaine M. de Souza-Fagundes、Helen A.J. Siqueira、Rodrigo S. Leite、Claudio L. Donnici、Carlos L. Zani

  DOI：10.1016/j.ejmech.2006.03.010

  日期：2006.6

  A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells. (c) 2006 Elsevier SAS. All rights reserved.
• 346. The constitution of natural phenolic resins. Part IX. The structure of lariciresinol and preliminary experiments on the synthesis of lignandiols
  作者：Robert D. Haworth、William Kelly

  DOI：10.1039/jr9370001645

  日期：——
• Substituted furans as inhibitors of the PDE4 enzyme
  作者：Hélène Perrier、Christopher Bayly、France Laliberté、Zheng Huang、Roberta Rasori、Annette Robichaud、Yves Girard、Dwight Macdonald

  DOI：10.1016/s0960-894x(98)00742-2

  日期：1999.2

  The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Traverso, Gazzetta Chimica Italiana, 1959, vol. 89, p. 1818,1823
  作者：Traverso

  DOI：——

  日期：——