6-Bromo-5H-benzophenoxazin-5-one | 50426-22-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 6-Bromo-5H-benzophenoxazin-5-one
• 英文别名: 6-bromo-benzo[a]phenoxazin-5-one；6-Brombenzophenoxazin-5-on；6-Bromo-5H-benzo[a]phenoxazin-5-one；6-bromobenzo[a]phenoxazin-5-one
• CAS: 50426-22-7
• 化学式: C₁₆H₈BrNO₂
• 分子量: 326.149
• InChiKey: KJDHUVPCFNMQHZ-UHFFFAOYSA-N

物化性质

• 熔点：
  196-197 °C(Solv: benzene (71-43-2))
• 沸点：
  381.6±42.0 °C(Predicted)
• 密度：
  1.65±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

SDS

反应信息

• 作为反应物：
  描述：

  6-Bromo-5H-benzophenoxazin-5-one 在 吡啶 、 sodium hydrogensulfite 作用下， 以 1,4-二氧六环 、 水 、 苯 为溶剂， 以97%的产率得到苯并[a]吩恶嗪-5-酮
  参考文献：
  名称：

  某些5 H-苯并[ a ]苯恶嗪-5-酮衍生物的合成

  摘要：

  取代的6-溴和6-氯-5 H-苯并[ a ]苯恶嗪-5-酮，是通过将取代的2-氨基酚与2,3-二溴或2,3-二氯-1,4-萘醌缩合而制得在溶解于吡啶水溶液中的亚硫酸氢钠存在下，在氮气氛下，将氢氧化钾甲醇溶液脱卤成取代的5 H-苯并[ a ]苯恶嗪-5-酮。

  DOI：

  10.1002/jhet.5570190136
• 作为产物：
  描述：

  苯并[a]吩恶嗪-5-酮 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 氯仿 为溶剂， 反应 1.5h， 生成 6-Bromo-5H-benzophenoxazin-5-one
  参考文献：
  名称：

  Investigations in the field of the chemistry of phe noxazines

  摘要：

  DOI：

  10.1007/bf00474787

文献信息

• Saccharide sensing molecules having enhanced fluorescent properties
  申请人：——

  公开号：US20020010279A1

  公开（公告）日：2002-01-24

  The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

  本发明提供了一种荧光化合物的配方，具有多种特性，使它们非常适合用于传感器中，用于分析物如糖类。有利的荧光特性包括有利的激发波长、发射波长、荧光寿命和光稳定性。其他有利的特性包括增强的水溶性，以及温度和pH敏感性。该化合物包括作为底物识别组分、荧光开关组分和荧光物质的芳基或取代苯基硼酸。描述了被激发波长大于400纳米并且发射波长大于450纳米的荧光化合物，这对于通过皮肤进行光传输是有利的。荧光物质通常选自过渡金属配体络合物和噻嗪、噁嗪、噁醛或噻嗪-1以及蒽化合物。该荧光化合物可以固定在葡萄糖渗透生物相容性聚合物基质中，该基质可植入皮肤下方。
• Fluorescent lifetime assays for non-invasive quantification of analytes such as glucose
  申请人：——

  公开号：US20020043651A1

  公开（公告）日：2002-04-18

  The invention disclosed herein provides fluorescence based methods for the determination of polyhydroxylated analyte concentrations as well as optical polyhydroxylate analyte sensors and sensor systems. In particular, the invention provides methods of quantifying the abundances or concentrations of polyhydroxylate analyte by measuring changes in the fluorescence lifetimes. The methods of the invention are based on the observation that fluorescent sensor molecules capable of binding a polyhydroxylated analyte such as glucose have distinct fluorescent lifetimes depending upon whether they are in a form that is either bound to analyte or a form that is not bound to the analyte. The distinct and measurable differences in the fluorescence lifetimes of the different fluorescent sensor species can be used to determine the relative abundance of the bound and unbound fluorescent sensor species, a parameter which can then be correlated to the concentration of the analyte.

  本发明提供了基于荧光的方法，用于测定多羟基分析物浓度，以及光学多羟基分析物传感器和传感器系统。特别地，本发明提供了通过测量荧光寿命变化来量化多羟基分析物丰度或浓度的方法。本发明的方法基于以下观察结果：能够结合多羟基分析物（如葡萄糖）的荧光传感器分子，其荧光寿命取决于它们是与分析物结合的形式还是未结合分析物的形式。不同和可测量的荧光传感器物种的荧光寿命的差异可以用于确定结合和未结合荧光传感器物种的相对丰度，该参数可以与分析物的浓度相关联。
• UENO, YOSHIO;MAEDA, KEIICHI;KOSHITANI, JINYA;YOSHIDA, TAKATOSHI, J. HETEROCYCL. CHEM., 1982, 19, N 1, 189-191
  作者：UENO, YOSHIO、MAEDA, KEIICHI、KOSHITANI, JINYA、YOSHIDA, TAKATOSHI

  DOI：——

  日期：——
• GLUCOSE SENSING MOLECULES HAVING SELECTED FLUORESCENT PROPERTIES
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP1214596A1

  公开（公告）日：2002-06-19
• EXTERIOR REFLECTIVE MIRROR ELEMENT FOR A VEHICULAR REARVIEW MIRROR ASSEMBLY
  申请人：Varaprasad Desaraju V.

  公开号：US20100053723A1

  公开（公告）日：2010-03-04

  An exterior reflective mirror element suitable for a vehicle includes a transparent glass substrate having a reflector and a visual indicator display disposed to the rear of the substrate. The visual indicator display may be part of a blind spot detection and display system of the vehicle wherein the visual indicator display is actuated to emit light responsive to a detection by a blind spot detection detector of the equipped vehicle of an overtaking vehicle in a side lane adjacent the side of the equipped vehicle. The visual indicator display includes at least a first indicator at a first location to the rear of the exterior reflective mirror element. A first portion of the reflector may be at least partially removed at the first location in order to establish an at least partially transmissive first portion of the exterior reflective mirror element at the first location.