3-hydroxy-1-(2-naphthyl)-3-(1-naphthyl)butan-1-one oxime | 653602-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-hydroxy-1-(2-naphthyl)-3-(1-naphthyl)butan-1-one oxime
• 英文别名: 4-(Hydroxyimino)-2-(naphthalen-1-yl)-4-(naphthalen-2-yl)butan-2-ol；4-hydroxyimino-2-naphthalen-1-yl-4-naphthalen-2-ylbutan-2-ol
• CAS: 653602-00-7
• 化学式: C₂₄H₂₁NO₂
• 分子量: 355.436
• InChiKey: MMJZDSZHMJATRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-1-(2-naphthyl)-3-(1-naphthyl)butan-1-one oxime 在 甲烷磺酸 作用下， 以 苯 为溶剂， 以30%的产率得到5-methyl-5-(1-naphthyl)-3-(2-naphthyl)-4,5-dihydro-1,2-oxazole
  参考文献：
  名称：

  The Preparation of 5-Aryl-5-methyl-4,5-dihydroisoxazoles from Dilithiated C(α), O -Oximes and Select Acetyl Ketones

  摘要：

  Several 5-aryl-5-methyl-4,5-dihydroisoxazoles were prepared by a three-step, one-pot process in 24-83% yield. C(alpha),O-oximes were dilithiated with lithium diisopropylamide and condensed with electron enriched acetophenones, such as 4'-methoxyacetophenone, followed by immediate acid cyclization.

  DOI：

  10.1081/scc-120026359
• 作为产物：
  描述：

  1-萘乙酮 、 2-acetonaphthone oxime 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到3-hydroxy-1-(2-naphthyl)-3-(1-naphthyl)butan-1-one oxime
  参考文献：
  名称：

  The Preparation of 5-Aryl-5-methyl-4,5-dihydroisoxazoles from Dilithiated C(α), O -Oximes and Select Acetyl Ketones

  摘要：

  Several 5-aryl-5-methyl-4,5-dihydroisoxazoles were prepared by a three-step, one-pot process in 24-83% yield. C(alpha),O-oximes were dilithiated with lithium diisopropylamide and condensed with electron enriched acetophenones, such as 4'-methoxyacetophenone, followed by immediate acid cyclization.

  DOI：

  10.1081/scc-120026359