环己基二甲基铵乙酸盐 | 27147-10-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 环己基二甲基铵乙酸盐
• 中文别名: 乙酸环己基二甲基铵
• 英文名称: N,N-dimethylcyclohexylamine acetate
• 英文别名: dimethylcyclohexylammonium acetate；Cyclohexyldimethylammonium acetate；cyclohexyl(dimethyl)azanium;acetate
• CAS: 27147-10-0
• 化学式: C₂H₄O₂*C₈H₁₇N
• 分子量: 187.282
• InChiKey: LDQFAGZKMFMHFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods and compositions for determining the sequence of nucleic acid molecules
  申请人：QIAGEN Genomics, Inc.

  公开号：US20040115694A1

  公开（公告）日：2004-06-17

  Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.

  提供了用于确定核酸分子序列的方法和化合物，包括从中制备的组合物。该方法允许同时确定多个核酸序列。这些化合物被用作标记，以生成与所选目标核酸分子互补的带标记的核酸片段。每个标记与特定的核苷酸相关，在优选实施例中，可以通过质谱法检测到。在通过顺序长度分离带标记的片段后，将从带标记的片段中切除标记。在优选实施例中，通过质谱法检测标记，并从中确定核酸分子的序列。该方法的各个步骤可以以自动化格式使用，例如通过纳入系统中。
• METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID MOLECULES UTILIZING SIZING TECHNIQUES
  申请人：Van Ness Jeffrey

  公开号：US20060057566A1

  公开（公告）日：2006-03-16

  Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required.

  本发明揭示了专门设计用于各种核酸反应的标签和连接剂，适用于需要基于大小分离核酸分子的各种核酸反应。
• Isocyanate-crosslinked coating having reduced yellowing
  申请人：BASF CORPORATION

  公开号：EP0581040A1

  公开（公告）日：1994-02-02

  A coating composition is described for producing a clear or colorless coating. The composition comprises: (a) a polymer comprising at least one functional group that is reactive with isocyanate, (b) a blocked polyisocyanate, (c) a hydrazide group, either attached to the polymer (a), to the polyisocyanate (b), or part of a compound different from (a) or (b), wherein at least one of the nitrogens of the hydrazide group is not adjacent to a carbonyl.

  描述了一种用于生产透明或无色涂料的涂料组合物。该组合物包括 (a) 至少含有一个与异氰酸酯反应的官能团的聚合物、 (b) 封端多异氰酸酯、 (c) 一个酰肼基团，可连接到聚合物 (a)、多异氰酸酯 (b) 或不同于 (a) 或 (b) 的化合物的一部分，其中酰肼基团的至少一个硝基不与羰基相邻。
• Compositions and methods for enhancing hybridization specificity
  申请人：Rapigene, Inc.

  公开号：EP0952228A2

  公开（公告）日：1999-10-27

  Compositions and methods are provided for increasing the specificity of a probe nucleic acid for a target nucleic acid in a hybridization solution. An abasic residue, deoxyNebularine residue, or a hybotrope is used to increase specificity. A method is provided for identifying useful hybotropes, including salts, water miscible organic solvents, aprotic solvents and organic solvents, on the basis of enthalpy considerations. Hybotropic hybridization and modified oligonucleotides may be used in amplification reactions, such as PCR, sequence analysis methods, and genomic screening methods.

  本文提供了提高杂交溶液中探针核酸对目标核酸特异性的组合物和方法。使用消旋残基、脱氧星云残基或同源物来提高特异性。本研究提供了一种方法，可根据焓的考虑来确定有用的同素异形体，包括盐类、水溶性有机溶剂、烷基溶剂和有机溶剂。杂交和修饰寡核苷酸可用于扩增反应，如 PCR、序列分析方法和基因组筛选方法。
• Genotyping by liquid chromatographic analysis of short nucleic acid fragments
  申请人：Van Ness Jeffrey

  公开号：US20050089850A1

  公开（公告）日：2005-04-28

  The present invention provides genotyping analysis by liquid chromatographic analysis of short nucleic acid fragments. The nucleic acid fragments are amplification products using specifically designed oligonucleotides as primers and target nucleic acids containing nucleotides of interest as templates. The oligonucleotides contain recognition sequences for restriction endonucleases that cleave outside the recognition sequences. The short nucleic acid fragments can be rapidly and reliably analyzed using liquid chromatography, optionally followed by mass spectrometry, and the nucleotides of interest identified.

  本发明通过对短核酸片段进行液相色谱分析来提供基因分型分析。核酸片段是以专门设计的寡核苷酸为引物，以含有相关核苷酸的靶核酸为模板的扩增产物。寡核苷酸含有限制性内切酶的识别序列，限制性内切酶会在识别序列外裂解。使用液相色谱法可快速、可靠地分析短核酸片段，随后可选择使用质谱法，并鉴定出感兴趣的核苷酸。