4-hydroxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine | 183959-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-hydroxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine
• 英文别名: 1-(2-Hydroxy-1-phenylethoxy)-2,2,6,6-tetramethylpiperidin-4-ol
• CAS: 183959-05-9
• 化学式: C₁₇H₂₇NO₃
• 分子量: 293.406
• InChiKey: BWVUAECMGLUUGH-UHFFFAOYSA-N

物化性质

• 沸点：
  409.0±55.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  异氰酸丙酯 、 4-hydroxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine 在 dibutyltin(II) dilaurate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以99%的产率得到Propyl-carbamic acid 2,2,6,6-tetramethyl-1-(1-phenyl-2-propylcarbamoyloxy-ethoxy)-piperidin-4-yl ester
  参考文献：
  名称：

  Polyurethane Macroinitiator for Controlled Monomer Insertion of Styrene

  摘要：

  Polyurethane containing alkoxyamine units in the main chain were prepared by polyaddition of diisocyanate with TEMPO-based diol. Radical polymerization of styrene was carried out in bulk with TEMPO-based polyurethane as macroinitiator. GPC, NMR, and IR data revealed that the insertion reaction was accurately controlled to afford the segmented copolymers composed of both urethane groups and polystyrene segments. From the results of model polymerization, it is inferred that the well-defined polystyrene chains were inserted into the macroinitiator. The obtained polymers showed quite different solubility in solvents compared with the macroinitiator and styrene homopolymer. The solubility in polar solvents decreases gradually with increasing inserted polystyrene chain length.

  DOI：

  10.1021/ma021091i
• 作为产物：
  描述：

  Benzoic acid 2-(4-hydroxy-2,2,6,6-tetramethyl-piperidin-1-yloxy)-2-phenyl-ethyl ester 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以99%的产率得到4-hydroxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine
  参考文献：
  名称：

  动态共价芳族聚酰胺的触发结构控制：溶液和固态中热重组行为的影响

  摘要：

  合成了热重排芳族聚酰胺（TEMPO-PA）和无规共聚酰胺（TEMPO-PA-COOH）在主链中掺入烷氧基胺部分，并研究了热重组行为对其溶液和固态结构的影响。由于烷氧基胺单元的离解，溶液中的流体力学半径随溶液温度的升高而降低。另外，薄膜的干密度随着制造温度的升高而降低，这是由于抑制了由热引发的自由基交叉反应引起的聚合物聚集。另外，在含有疏水性TEMPO和亲水性3，5-二氨基苯甲酸（DABA）单元的无规共聚酰胺的膜表面，亲水性随着制造温度的升高而降低。这是因为疏水性TEMPO和亲水性DABA单元倾向于在膜表面附近离散地聚集，以最小化表面能并在薄膜制造过程中通过自由基穿越反应抑制氢键。本研究清楚地表明，动态共价聚合物的溶液结构和固态分子聚集结构都可以通过热触发容易地控制，这为控制聚合物溶液和固体的高阶结构提供了一种新方法。 。

  DOI：

  10.1021/acs.macromol.5b01778

文献信息

• Benzotriazoles containing phenyl groups substituted by heteroatoms and compositions stabilized therewith
  申请人：——

  公开号：US20030004235A1

  公开（公告）日：2003-01-02

  2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by a phenyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.

  3-位和/或5-位被苯基环上的苯基取代的2H-苯并三唑紫外线吸收剂，其被异原子取代的苯基特别在汽车涂料中具有光稳定性，并且在热塑性复合材料中具有低色度和低挥发性。
• Radical Crossover in Nitroxide Mediated “Living” Free Radical Polymerizations
  作者：Craig J. Hawker、George G. Barclay、Julian Dao

  DOI：10.1021/ja9624228

  日期：1996.1.1

  The results reveal that exchange of the mediating nitroxide free radicals is a facile process and at essentially all stages of the polymerization a nearly statistical mixture of crossover products is obtained. The HPLC techniques developed are also useful in evaluating the extent of chain termination in nitroxide mediated “living” free radical polymerizations.

  通过一系列使用官能化单分子引发剂的交叉实验，已经探讨了在“活性”自由基聚合过程中在聚合物链增长末端的介导氮氧化合物部分之间的交换效率。适当取代的引发剂的设计允许合成特定功能化的模型聚合物，使用高效液相色谱 (HPLC) 可以轻松区分这些聚合物。使用这些模型，从不同引发剂的 1:1 组合中获得的大分子混合物被分离和鉴定。结果表明，介导的氮氧自由基的交换是一个容易的过程，并且在聚合的基本上所有阶段都获得了几乎统计性的交叉产物混合物。
• Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof
  申请人：——

  公开号：US20040192927A1

  公开（公告）日：2004-09-30

  Compounds of formula I or II 1 where R is an aryl moiety, such as phenyl, naphthyl or biphenylyl, or is phenyl substituted by one or more trifluoromethyl, bromo or cyano, and E 1 and E 2 are independently hydrogen, alkyl, aralkyl and the like are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a arylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.

  化合物的公式I或II1，其中R是芳基基团，例如苯基，萘基或联苯基，或是被一个或多个三氟甲基，溴或氰取代的苯基，E1和E2独立地是氢，烷基，芳基烷基等，通过苯并三唑在苯环的5位被卤素原子取代，与芳基硼酸或酯在过渡金属催化剂的存在下，例如二乙酸钯（II）反应制备而成。公式I的苯并三唑化合物特别适用于汽车涂料和蜡烛蜡的稳定剂。
• Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith
  申请人：——

  公开号：US20010016658A1

  公开（公告）日：2001-08-23

  Hindered amines substituted on the N-atom with an —O—E—OH moiety are particularly effective in stabilizing polyolefin and automotive coating compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group on the compounds adds important properties not attainable by the use of normal —O—E moieties.

  在N原子上取代了一个—O—E—OH基团的阻碍胺对稳定聚烯烃和汽车涂料组合物，以对抗氧化、热和光辐射的有害影响特别有效，其中化合物上OH基团的存在增加了重要性质，这是正常的—O—E基团所无法达到的。
• Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith
  申请人：——

  公开号：US20010031872A1

  公开（公告）日：2001-10-18

  Hindered amines substituted on the N-atom with an —O—E—OH moiety are particularly effective in stabilizing polyolefin and automotive coating compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group on the compounds adds important properties not attainable by the use of normal —O—E moieties.

  在氮原子上取代了-O-E-OH基团的受阻胺在稳定聚烯烃和汽车涂料组合物抵抗氧化、热和光辐射的有害影响方面特别有效，其中化合物上OH基团的存在增加了重要的性质，这是使用正常的-O-E基团无法达到的。