[Au(en)Cl2]Cl | 12316-65-3

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: [Au(en)Cl2]Cl
• 英文别名: Ethane-1,2-diamine;gold(3+);trichloride；ethane-1,2-diamine;gold(3+);trichloride
• CAS: 12316-65-3
• 化学式: C₂H₈AuCl₂N₂*Cl
• 分子量: 363.424
• InChiKey: PLTJSFQSEIEJPY-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Au(en)Cl2]Cl 在 盐酸 作用下， 以 水 为溶剂， 生成 tetrachloroaurate(III)(1-)
  参考文献：
  名称：

  螯合配体从平面四坐标络合物的置换。第5部分。二氯（乙二胺）-和二氯（丙二胺）-金（III）配合物的制备和配体取代反应

  摘要：

  在盐酸介质中，I = 1.7 mol dm –3，研究了标题配合物[Au（en）Cl 2 ] +和[Au（pn）Cl 2 ] +中螯合配体（N–N）的取代。，使用甲醇水溶液（95％）或水作为溶剂。该反应分两个阶段进行：建立单配位和双配位二胺之间的初始平衡，然后从金属中置换单键质子化的配体。已经确定了螯合环的打开的速率常数和半分离的配体的位移，以及闭环的速率常数与半键合的二胺的碱度常数的商。比较与数据的类似的配体从钯Ⅱ和铂Ⅱ配合物置换。

  DOI：

  10.1039/dt9780000728
• 作为产物：
  描述：

  四氯金酸水合物 在 lithium hydroxide 、 乙二胺 作用下， 以 甲醇 为溶剂， 以80%的产率得到[Au(en)Cl2]Cl
  参考文献：
  名称：

  螯合配体从平面四坐标络合物的置换。第5部分。二氯（乙二胺）-和二氯（丙二胺）-金（III）配合物的制备和配体取代反应

  摘要：

  在盐酸介质中，I = 1.7 mol dm –3，研究了标题配合物[Au（en）Cl 2 ] +和[Au（pn）Cl 2 ] +中螯合配体（N–N）的取代。，使用甲醇水溶液（95％）或水作为溶剂。该反应分两个阶段进行：建立单配位和双配位二胺之间的初始平衡，然后从金属中置换单键质子化的配体。已经确定了螯合环的打开的速率常数和半分离的配体的位移，以及闭环的速率常数与半键合的二胺的碱度常数的商。比较与数据的类似的配体从钯Ⅱ和铂Ⅱ配合物置换。

  DOI：

  10.1039/dt9780000728
• 作为试剂：
  描述：

  咪唑 在 [Au(en)Cl2]Cl 、 重水 作用下， 生成
  参考文献：
  名称：

  Investigation of the interaction of gold(III)–alkyldiamine complexes with l-histidine and imidazole ligands by 1H and 13C NMR, and UV spectrophotometry

  摘要：

  Reactions of Au(III)-alkyldiamine complex with L-histidine and imidazole were carried out and monitored time-dependant by H-1 and C-13 NMR. Kinetics for the [Au(en)Cl-2](+) reaction with L-histidine was determined by initial rate method at constant pH and 25 degrees C using UV-Vis absorption technique, and found to be first order with respect to each component, with a pseudo second order rate constant of 39 +/- 3 M-1 s(-1). Reaction rates of L-histidine and imidazole reactions with the [Au(en)Cl-2](+) complex was found to be strongly dependant on pD. The pD also has profound effect on the stability of the complex. It was observed that concurrent redox reactions also take place in solution in which Au(III) is reduced to metallic Au(0), while L-histidine and imidazole are oxidized to oxy and hydroxyl products. The optimization of the structure of [(His)Au(en)](3+) complex was carried out by GAUSSIAN03 at the RB3LYP level that showed a distorted square pyramid with the histidine carboxyl group at the pyramid top. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.05.059

文献信息

• Synthesis of MCF-supported AuCo nanoparticle catalysts and the catalytic performance for the CO oxidation reaction
  作者：Lin Li、Song-Hai Chai、Andrew Binder、Suree Brown、Shi-Ze Yang、Sheng Dai

  DOI：10.1039/c5ra11487j

  日期：——

  AuCo/MCF calcined at 500 °C for 1 h was found to produce the most active and stable catalyst for CO oxidation. In situ FTIR results of AuCo/MCF catalysts with different treatments.

  在500°C下煅烧1小时的AuCo/MCF被发现能产生对CO氧化最活性和稳定的催化剂。不同处理的AuCo/MCF催化剂的原位FTIR结果。
• Some new [(thione)2Au(diamine)]Cl3 complexes: Synthesis, spectroscopic characterization, computational and in vitro cytotoxic studies
  作者：Bassem A. Al-Maythalony、M. Monim-ul-Mehboob、Muhammad Altaf、Mohammed I.M. Wazeer、Anvarhusein A. Isab、Saleh Altuwaijri、Ayesha Ahmed、Vikram Dhuna、Gaurav Bhatia、Kshitija Dhuna、Sukhdev Singh Kamboj

  DOI：10.1016/j.saa.2013.06.086

  日期：2013.11

  Recent advances in oncology are focused on developing new complexes of gold(III) with various ligands that show augmented anti-proliferative potential and reduced toxicity as compared to cis-platin. In this study, new Au(III) complexes of the type [(thione)(2)Au(diamine)]Cl-3 are reported, where thione = 1,3-imidazolidine-2-thione (Imt), 1,3-Diazinane-2-thione (Diaz) and diamine = 1,2-diaminoethane (en), 1,3-diaminopropane (pn) or 1,4-diaminobutane (bn). The solid state IR as well as C-13 and N-15 NMR data indicate that Au(III) center is bonded via sulfur of thiocarbonyl S=C site of the thiones and also chelated by the diamines from the trans side of coordinated thiones. Spectroscopic data are evaluated by comparisons with calculated data from the built and optimized structure by GAUSSIAN 09 at the RB3LYP level with LanL2DZ bases set. These new Au(III) complexes based on mixed thione and diamine ligands are very similar to the square planar structure of tetracoordinate [Au(en)(2)]Cl(3)complex. In this study, cytotoxicity data for these gold(III) complexes against C6 glioma cell lines are also reported, and the results indicate some complexes have cytotoxicity comparable to cis-platin. (C) 2013 Elsevier B.V. All rights reserved.
• Displacement of chelate ligands from planar four-co-ordinate complexes. Part 5. Preparation and ligand-substitution reaction of di-chloro(ethylenediamine)- and dichloro(propylenediamine)-gold(III) complexes
  作者：Giuliano Annibale、Giovanni Natile、Bruno Pitteri、Lucio Cattalini

  DOI：10.1039/dt9780000728

  日期：——

  The displacement of the chelate ligand (N–N) from the title complexes [Au(en)Cl2]+ and [Au(pn)Cl2]+ has been studied in a hydrochloric acid medium, I= 1.7 mol dm–3, using aqueous methanol (95%) or water as solvent. The reaction takes place in two stages: an initial equilibrium between singly and doubly co-ordinate diamine is established, followed by displacement of the singly bonded protonated ligand

  在盐酸介质中，I = 1.7 mol dm –3，研究了标题配合物[Au（en）Cl 2 ] +和[Au（pn）Cl 2 ] +中螯合配体（N–N）的取代。，使用甲醇水溶液（95％）或水作为溶剂。该反应分两个阶段进行：建立单配位和双配位二胺之间的初始平衡，然后从金属中置换单键质子化的配体。已经确定了螯合环的打开的速率常数和半分离的配体的位移，以及闭环的速率常数与半键合的二胺的碱度常数的商。比较与数据的类似的配体从钯Ⅱ和铂Ⅱ配合物置换。
• Investigation of the interaction of gold(III)–alkyldiamine complexes with l-histidine and imidazole ligands by 1H and 13C NMR, and UV spectrophotometry
  作者：Bassem A. Al-Maythalony、Anvarhusein A. Isab、Mohammed I.M. Wazeer、Abdellatif Ibdah

  DOI：10.1016/j.ica.2010.05.059

  日期：2010.10

  Reactions of Au(III)-alkyldiamine complex with L-histidine and imidazole were carried out and monitored time-dependant by H-1 and C-13 NMR. Kinetics for the [Au(en)Cl-2](+) reaction with L-histidine was determined by initial rate method at constant pH and 25 degrees C using UV-Vis absorption technique, and found to be first order with respect to each component, with a pseudo second order rate constant of 39 +/- 3 M-1 s(-1). Reaction rates of L-histidine and imidazole reactions with the [Au(en)Cl-2](+) complex was found to be strongly dependant on pD. The pD also has profound effect on the stability of the complex. It was observed that concurrent redox reactions also take place in solution in which Au(III) is reduced to metallic Au(0), while L-histidine and imidazole are oxidized to oxy and hydroxyl products. The optimization of the structure of [(His)Au(en)](3+) complex was carried out by GAUSSIAN03 at the RB3LYP level that showed a distorted square pyramid with the histidine carboxyl group at the pyramid top. (C) 2010 Elsevier B.V. All rights reserved.