1-methyl-3-naphthalene-2-methylthiourea | 915280-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-methyl-3-naphthalene-2-methylthiourea
• 英文别名: 1-Methyl-3-(naphthalen-1-ylmethyl)thiourea
• CAS: 915280-00-1
• 化学式: C₁₃H₁₄N₂S
• 分子量: 230.334
• InChiKey: SBMDADJNXKLVAV-UHFFFAOYSA-N

物化性质

• 沸点：
  384.5±35.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲硫脲 、 2-溴甲基萘 以 甲醇 为溶剂， 以57%的产率得到1-methyl-3-naphthalene-2-methylthiourea
  参考文献：
  名称：

  NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORalpha AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

  摘要：

  提供的是一种激活RORα基因的化合物，特别是一种含有CGP52608噻唑烷二酮作为主要物质的JC1化合物，以及其药用盐。该化合物是一种脂肪积聚抑制剂，适用于治疗代谢性疾病或炎症性疾病。

  公开号：

  US20180265462A1

文献信息

• Non-Peptidic Inhibitors of AKAP/PKA Interaction
  申请人：Klussmann Enno

  公开号：US20090176773A1

  公开（公告）日：2009-07-09

  The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
• NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORalpha AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：LEE Mi Ock

  公开号：US20180265462A1

  公开（公告）日：2018-09-20

  Provided is a compound activating RORα gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.

  提供的是一种激活RORα基因的化合物，特别是一种含有CGP52608噻唑烷二酮作为主要物质的JC1化合物，以及其药用盐。该化合物是一种脂肪积聚抑制剂，适用于治疗代谢性疾病或炎症性疾病。