1-Dimethylamino-3-thia-hexan | 17471-21-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Dimethylamino-3-thia-hexan
• 英文别名: N,N-dimethyl-2-propylsulfanylethanamine
• CAS: 17471-21-5
• 化学式: C₇H₁₇NS
• 分子量: 147.285
• InChiKey: UDYYYVZEMGEHHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙烷-1-硫醇 、 2-氯-N,N-二甲基乙胺 在 sodium 作用下， 以 乙醇 为溶剂， 生成 1-Dimethylamino-3-thia-hexan
  参考文献：
  名称：

  Reaction of sulfenes with 1,3-bis(dimethylamino)-1-alkenes. Mechanistic dichotomy as a function of substitution

  摘要：

  DOI：

  10.1021/ja00992a027

文献信息

• [EN] IMMUNOPHILIN BINDING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE LIAISON À L'IMMUNOPHILINE ET LEURS UTILISATIONS
  申请人：UNIV CALIFORNIA

  公开号：WO2020163594A1

  公开（公告）日：2020-08-13

  Described herein, inter alia, are immunophilin binding compounds and methods of treating CNS diseases, including co-administering outside the CNS of a subject an anti-CNS disease drug and a compound described herein.

  本文描述了免疫蛋白结合化合物以及治疗中枢神经系统疾病的方法，包括在主体的中枢神经系统外联合给予一种抗中枢神经系统疾病药物和本文描述的化合物。
• BIO-ELECTRODE COMPOSITION, BIO-ELECTRODE, METHOD FOR MANUFACTURING THE BIO-ELECTRODE, AND POLYMER COMPOUND
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3358572B1

  公开（公告）日：2021-12-01
• [EN] HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASE POUR L'ACCROISSEMENT DE L'ACTIVITÉ D'AGENTS ANTIFONGIQUES
  申请人：METHYLGENE INC

  公开号：WO2014041424A1

  公开（公告）日：2014-03-20

  The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, the invention relates to compounds, compositions thereof, and methods for selectively enhancing fungal sensitivity to antifungal compounds. The compositions of the invention are comprised of a combination of a histone deacetylase inhibitor, or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, agricultural formulation, prodrug or complex thereof, and an antifungal agent, the histone deacetylase inhibitor being a compound of Formula (I).
• [EN] RNA REPLICON VACCINES AGAINST HBV<br/>[FR] VACCINS À BASE DE RÉPLICON D'ARN CONTRE LE VHB
  申请人：JANSSEN SCIENCES IRELAND UNLIMITED CO

  公开号：WO2022008613A1

  公开（公告）日：2022-01-13

  Nucleic acid molecules encoding hepatitis B virus (HBV) surface antigens, HBV core antigens, and HBV polymerase antigens, and related combinations, are described. Also described are vectors, such as DNA plasmids or viral vectors, and RNA replicons, expressing the HBV antigens, and pharmaceutical compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the pharmaceutical compositions of the invention are also described.
• Reaction of sulfenes with 1,3-bis(dimethylamino)-1-alkenes. Mechanistic dichotomy as a function of substitution
  作者：Leo A. Paquette、Melvin H. Rosen

  DOI：10.1021/ja00992a027

  日期：1967.8