2-bromo-4-methyl-cyclohexanecarboxylic acid | 70905-09-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2-bromo-4-methyl-cyclohexanecarboxylic acid
• 英文别名: 2-Brom-4-methyl-cyclohexancarbonsaeure；2-bromo-4-methylcyclohexanecarboxylic acid；2-Bromo-4-methylcyclohexane-1-carboxylic acid
• CAS: 70905-09-8
• 化学式: C₈H₁₃BrO₂
• 分子量: 221.094
• InChiKey: JTXMNOKWBVFOOE-UHFFFAOYSA-N

物化性质

• 熔点：
  133-134 °C
• 沸点：
  304.4±35.0 °C(Predicted)
• 密度：
  1.444±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基环己烯-1-羧酸 在 氢溴酸 作用下， 生成 2-bromo-4-methyl-cyclohexanecarboxylic acid
  参考文献：
  名称：

  Chou; Perkin, Journal of the Chemical Society, 1911, vol. 99, p. 537

  摘要：

  DOI：

文献信息

• Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
  申请人：University of Illinois Foundation

  公开号：EP0048149A1

  公开（公告）日：1982-03-24

  Novel antibiotics named didenmins A, B and C and nordidemnins A, B and C have been obtained from a marine organism named Trididemnum sp. These antibiotics are active against a variety of DNA and RNA viruses.

  从一种名为 Trididemnum sp.的海洋生物中获得了名为 didenmins A、B 和 C 以及 nordidemnins A、B 和 C 的新型抗生素。
• Glycosides isolated from the Euphorbiaceae genus Phyllanthus and their anti-tumour use
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0087861A1

  公开（公告）日：1983-09-07

  New antineoplastic glycosides, phyllanthostatin 1,2 and 3, of formula: and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.

  从中美洲树种 Phyllanthus acuminatus Vahl 中分离出了新的抗肿瘤苷--式：的 phyllanthostatin 1、2 和 3，以及相关的苷--phyllanthoside。 这些化合物对美国国家癌症研究所的 P388 淋巴细胞白血病具有活性。 此外，还发现 phyllanthoside 对小鼠 B16 恶性肿瘤具有治疗活性。
• Bryozoan antibiotics
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0109811A2

  公开（公告）日：1984-05-30

  Potent antineoplastic agents designated bryostatin 1, bryostatin 2 and bryostatin 3 have been isolated from the marine animal Bugula neritina L. (Bryozoan phylum).

  从海洋动物 Bugula neritina L.（毛环节动物门）中分离出了强效抗肿瘤药物，分别命名为白僵菌素 1、白僵菌素 2 和白僵菌素 3。
• Antibiotics
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：EP0133000A2

  公开（公告）日：1985-02-13

  New antibiotics, which have been named Eudistomins, have been obtained from marine organisms. These compounds, which can have anti-viral, as well as anti-bacteria and anti-tumour activity in some cases, are, chemically, derivatives of 5H-pyrido[3,4-b]indole.

  从海洋生物中获得了被命名为 Eudistomins 的新型抗生素。这些化合物在某些情况下具有抗病毒、抗菌和抗肿瘤活性，在化学上是 5H-吡啶并[3,4-b]吲哚的衍生物。
• Antineoplastic quinones and methods of using same
  申请人：RESEARCH CORPORATION TECHNOLOGIES, INC.

  公开号：EP0449649A2

  公开（公告）日：1991-10-02

  New cytotoxic quinones, designated azamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases. Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

  研究发现，新的细胞毒性醌类化合物，即偶氮脒烯类和亚氨基偶氮脒烯类，对卵巢肿瘤、结肠癌、肌瘤和类似的肿瘤疾病具有显著的活性。 公开了利用偶氮米苷和亚氨基偶氮米苷及其药用活性衍生物的药物制剂和治疗方案。