3-(1,3-Dioxan-2-yl)propanenitrile | 80692-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 3-(1,3-Dioxan-2-yl)propanenitrile
• CAS: 80692-35-9
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: CCWLKBDKZGBCEY-UHFFFAOYSA-N

物化性质

• 沸点：
  265.6±15.0 °C(Predicted)
• 密度：
  1.037±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  42.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(1,3-Dioxan-2-yl)propanenitrile 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 3-(1,3-dioxan-2-yl)propanal
  参考文献：
  名称：

  乳精和非天然类似物的合成和生物学评价

  摘要：

  在这封信中，我们描述了第一次全合成 cremastrine，一种来自Cremastra appendiculata的吡咯里西啶生物碱，具有抗胆碱能活性以及非天然类似物。简化的合成分九步进行，最长的线性序列为七步，总产率为 25.2%，并具有构建吡咯里西啶核心的新方法。cremastrine 和非天然类似物的生物学评价表明两者都是泛-mAChR 功能性拮抗剂。

  DOI：

  10.1016/j.tetlet.2012.05.009
• 作为产物：
  描述：

  sodium cyanide 、 2-(2-溴乙基)-1,3-二氧杂环己烷 在 四丁基碘化铵 作用下， 以 二甲基亚砜 为溶剂， 生成 3-(1,3-Dioxan-2-yl)propanenitrile
  参考文献：
  名称：

  乳精和非天然类似物的合成和生物学评价

  摘要：

  在这封信中，我们描述了第一次全合成 cremastrine，一种来自Cremastra appendiculata的吡咯里西啶生物碱，具有抗胆碱能活性以及非天然类似物。简化的合成分九步进行，最长的线性序列为七步，总产率为 25.2%，并具有构建吡咯里西啶核心的新方法。cremastrine 和非天然类似物的生物学评价表明两者都是泛-mAChR 功能性拮抗剂。

  DOI：

  10.1016/j.tetlet.2012.05.009

文献信息

• Process For Preparing Pleuromutilin
  申请人：California Institute of Technology

  公开号：US20190106400A1

  公开（公告）日：2019-04-11

  The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.

  本公开提供了制备(+)-普鲁罗木杆菌素和由此制备的合成(+)-普鲁罗木杆菌素的过程。还提供了由此制备的中间体以及制备这些中间体的过程。
• Cyclopentaannulation of podocarpic acid derivatives via (η6-arene)tricarbonylchromium(O) complexes; ring D modification
  作者：Richard C. Cambie、Peter S. Rutledge、Ralph J. Stevenson、Paul D. Woodgate

  DOI：10.1016/0022-328x(94)88117-0

  日期：1994.5

  Functionalization of the (η6-arene)tricarbonylchromium(O) complexes of some podocarpic acid (1) derivatives has been achieved via addition-oxidation methodology. The resulting decomplexed products underwent Lewis acid-mediated cyclopentaannulation to give ring-C aromatic androstane analogues in high yield. The D rings of these steroidal analogues were modified by both oxidation and reduction sequences

  的官能化的（η 6 -arene）tricarbonylchromium（O）一些罗汉松酸的复合物（1）的衍生物已经达到通过添加氧化方法。所得的解复合产物经过路易斯酸介导的环戊环化反应，以高收率得到环C芳族雄甾烷类似物。这些类固醇类似物的D环通过氧化和还原序列进行修饰，在结构上类似于某些C15或C17氧化的天然存在的类固醇。
• Process for preparing pleuromutilin
  申请人：California Institute of Technology

  公开号：US10626099B2

  公开（公告）日：2020-04-21

  The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates prepared thereby and processes for preparing these intermediates.

  本公开提供了制备(+)-pleuromutilin 和由其生产的合成(+)-pleuromutilin 的工艺。还提供了由此制备的中间体和制备这些中间体的工艺。
• NONAQUEOUS ELECTROLYTIC SOLUTION AND ENERGY DEVICE INCLUDING THE SAME
  申请人：Mitsubishi Chemical Corporation

  公开号：US20200388884A1

  公开（公告）日：2020-12-10

  A nonaqueous electrolytic solution including a nonaqueous solvent and a compound represented by Formula (1). (wherein, in Formula (1), R 1 to R 5 each independently represent a hydrogen atom or an alkyl group that has 1 to 3 carbon atoms and may have a substituent; R 6 is an organic group that has 1 to 8 carbon atoms and may have a hetero atom; X is a carbon atom, a sulfur atom, or a phosphorus atom; when X is a carbon atom, l=0, m=1, and n=1, when X is a sulfur atom, l=0, m=2, and n=1, and when X is a phosphorus atom, l=0, m=1, and n=2 or l=1, m=1, and n=1; k is an integer of 2 to 4; and Y is a direct bond or a linking group that has 1 to 8 carbon atoms and may have a hetero atom, and when Y is a direct bond, the compound has an X—X bond and k=2).
• NONAQUEOUS ELECTROLYTIC SOLUTION AND ELECTRICAL STORAGE DEVICE INCLUDING THE SAME
  申请人：Mitsubishi Chemical Corporation

  公开号：US20200388887A1

  公开（公告）日：2020-12-10

  A nonaqueous electrolytic solution including an electrolyte, a nonaqueous solvent, and a compound represented by Formula (1) below. (in Formula (1), X 1 and X 2 each independently represent C, S, or P; n 1 and n 2 each independently represent 1 when X 1 and X 2 represent C or P and 2 when X 1 and X 2 represent S; n 1 represents 1 or 2; n 2 represents 1 or 2; Y 1 and Y 2 each independently represent a hydrocarbon group that may have a substituent or an —OW group (where W represents a hydrocarbon group that may have a substituent); m 1 represents 1 or 2, and m 2 represents 1 or 2; and Z represents a hydrocarbon group that may have a substituent, an —SiV 3 group (where V represents a hydrocarbon group that may have a substituent), an organic onium, or a metal).