(5R,8aR)-5-dec-2-ynyl-1,2,3,5,6,7,8,8a-octahydroindolizine | 304011-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: (5R,8aR)-5-dec-2-ynyl-1,2,3,5,6,7,8,8a-octahydroindolizine
• CAS: 304011-58-3
• 化学式: C₁₈H₃₁N
• 分子量: 261.451
• InChiKey: HANVXTAOTSAFKY-ZWKOTPCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (5R,8aR)-5-dec-2-ynyl-1,2,3,5,6,7,8,8a-octahydroindolizine 在 氨 、 sodium 作用下， 生成 (5R,8aR)-5-<(E)-dec-2-enyl>octahydroindolizine
  参考文献：
  名称：

  The total synthesis of piclavines A1–4 and their biological evaluation

  摘要：

  The total synthesis of piclavines A1, A2, A3, and A4 has been achieved starting from compound 10 with enantiomeric enhancement. Their biological activities (antibacterial, antimicrobacterial, and antiviral activities and inhibition of cell growth) were evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00341-3
• 作为产物：
  描述：

  1-壬炔 在 10% Cd/Pd 吡啶 、 正丁基锂 、 碘代三甲硅烷 、 potassium carbonate 作用下， 生成 (5R,8aR)-5-dec-2-ynyl-1,2,3,5,6,7,8,8a-octahydroindolizine
  参考文献：
  名称：

  The total synthesis of piclavines A1–4 and their biological evaluation

  摘要：

  The total synthesis of piclavines A1, A2, A3, and A4 has been achieved starting from compound 10 with enantiomeric enhancement. Their biological activities (antibacterial, antimicrobacterial, and antiviral activities and inhibition of cell growth) were evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00341-3