diethyl 4-oxo-4H-indeno[1,2-b]furan-2,3-dicarboxylate | 1325716-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: diethyl 4-oxo-4H-indeno[1,2-b]furan-2,3-dicarboxylate
• 英文别名: Diethyl 4-oxoindeno[1,2-b]furan-2,3-dicarboxylate；diethyl 4-oxoindeno[1,2-b]furan-2,3-dicarboxylate
• CAS: 1325716-42-4
• 化学式: C₁₇H₁₄O₆
• 分子量: 314.295
• InChiKey: XTZRRBMQZJRMTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  82.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,3-茚满二酮 、 丁炔二酸二乙酯 在 氧气 、 甲胺 、 丙二腈 作用下， 反应 0.5h， 以78%的产率得到diethyl 4-oxo-4H-indeno[1,2-b]furan-2,3-dicarboxylate
  参考文献：
  名称：

  Efficient atom economical one-pot multicomponent synthesis of densely functionalized 4H-chromene derivatives

  摘要：

  A sequential one-pot, atom economical three component reaction yielding medicinally promising ethyl 2-amino-3-cyano-4-(2-ethoxy-2-oxoethyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-4-carboxylate derivatives (4a-f) through a tandem Michael addition-cyclization reaction starting with structurally diverse cyclohexane-1,3-dione, diethyl acetylene dicarboxylate, and malononitrile has been carried out in different organic bases under solvent free condition for the optimization of maximum yield. All the formed 4H-chromenes were characterized by spectral and X-ray methods. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.06.021

文献信息

• Efficient atom economical one-pot multicomponent synthesis of densely functionalized 4H-chromene derivatives
  作者：Muthusamy Boominathan、Muthupandi Nagaraj、Shanmugam Muthusubramanian、Rajaputi Venkatraman Krishnakumar

  DOI：10.1016/j.tet.2011.06.021

  日期：2011.8

  A sequential one-pot, atom economical three component reaction yielding medicinally promising ethyl 2-amino-3-cyano-4-(2-ethoxy-2-oxoethyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-4-carboxylate derivatives (4a-f) through a tandem Michael addition-cyclization reaction starting with structurally diverse cyclohexane-1,3-dione, diethyl acetylene dicarboxylate, and malononitrile has been carried out in different organic bases under solvent free condition for the optimization of maximum yield. All the formed 4H-chromenes were characterized by spectral and X-ray methods. (C) 2011 Elsevier Ltd. All rights reserved.