2-氨基甲基-6-甲基哌嗪 | 1122585-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-氨基甲基-6-甲基哌嗪
• 英文名称: 2-aminomethyl-6-methylpiperazine
• 英文别名: (6-Methylpiperazin-2-yl)methanamine
• CAS: 1122585-40-3
• 化学式: C₆H₁₅N₃
• mdl: MFCD18072985
• 分子量: 129.205
• InChiKey: YWDBOOQOEFVBRX-UHFFFAOYSA-N

物化性质

• 沸点：
  202.7±8.0 °C(Predicted)
• 密度：
  0.901±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甘油 在 catalyst precursor whose active composition comprised 50% by weight of Ni, calculated as NiO, 18% by weight of Cu, calculated as CuO, 2% by weight of Mo, calculated as MoO₃, and 30% by weight or Zr, calculated as ZrO₂ 氨 、 氢气 作用下， 以 水 为溶剂， 192.0 ℃ 、20.0 MPa 条件下， 反应 1076.0h， 生成 DL-氨基丙醇 、 2,3-二氨基-1-丙醇 、 丙烷-1,2,3-三胺 、 2-氨基甲基-6-甲基哌嗪 、 2,5-bis(aminomethyl)piperazine 、 2-氨基甲基哌嗪 、 2-aminomethyl-5-methylpiperazine 、 2-甲基哌嗪 、 1,2-丙二胺 、 2,6-二甲基哌嗪 、 2,5-二甲基哌嗪
  参考文献：
  名称：

  METHOD FOR PRODUCING AMINES FROM GLYCERIN

  摘要：

  本发明涉及一种通过在催化剂存在下，将甘油与氢气和来自氨和一次和二次胺组的氨化剂反应，在温度从100°C至400°C和压力从0.01至40兆帕（从0.1至400巴）条件下制备胺的方法。优选使用基于可再生原料的甘油。催化剂优选包括元素周期表第8和/或9和/或10和/或11族金属或多种金属或这些金属的一个或多个氧化物。该发明还涉及将反应产物用作水泥或混凝土生产中的添加剂以及其他用途领域。该发明还提供了化合物1,2,3-三胺丙烷，2-氨基甲基-6-甲基哌嗪，2,5-双(氨基甲基)哌嗪和2,6-双(氨基甲基)哌嗪。

  公开号：

  US20100240894A1

文献信息

• METHOD FOR PRODUCING AMINES FROM SUGAR ALCOHOLS
  申请人：Ernst Martin

  公开号：US20100311973A1

  公开（公告）日：2010-12-09

  The present invention relates to a process for preparing amines by reacting sugar alcohols with hydrogen and an aminating agent selected from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 1 to 40 MPa (from 10 to 400 bar). The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The sugar alcohol is preferably obtained by hydrogenating the corresponding sugars. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use.

  本发明涉及一种通过在催化剂存在下将糖醇与氢气和从氨和一次和二次胺组成的氨化剂中选择的一种反应制备胺的方法，所述方法在温度为100°C至400°C和压力为1至40 MPa（从10至400巴）的条件下进行。催化剂优选包括周期表元素8和/或9和/或10和/或11族金属或多种金属或金属的一种或多种氧化合物。糖醇优选通过将相应的糖进行氢化而获得。本发明还涉及将反应产物用作水泥或混凝土生产中的添加剂以及在其他领域中的用途。
• Heteroaryl alkyl piperazine derivatives
  申请人：——

  公开号：US20030216409A1

  公开（公告）日：2003-11-20

  Novel compounds of the general formula: 1 and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of diabetes, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

  通用公式：1的新化合物及其药学上可接受的酸盐，其中这些化合物在治疗中用于保护骨骼肌免受外伤引起的损伤或在骨骼肌或系统性疾病（如间歇性跛行）后保护骨骼肌，用于治疗休克状态，保护供体组织和器官用于移植，治疗糖尿病，治疗心血管疾病，包括心房和心室心律失常，普林兹梅塔（变异）心绞痛，稳定型心绞痛和运动诱发性心绞痛，充血性心脏病和心肌梗死。
• Heteroaryl alkyl piperazine derivatives as fatty acid oxidation inhibitors
  申请人：——

  公开号：US20040029889A1

  公开（公告）日：2004-02-12

  Novel compounds of the general formula (I): and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction. 1

  一般式（I）的新化合物及其药物可接受的酸盐，其中这些化合物在治疗中对保护骨骼肌免受创伤引起的损伤或在肌肉或全身疾病（如间歇性跛行）后保护骨骼肌，治疗休克病状，保存用于移植的供体组织和器官，在治疗心血管疾病包括心房和心室心律失常，普林兹梅塔尔（变异）心绞痛，稳定型心绞痛和运动性心绞痛，充血性心力衰竭和心肌梗死方面有用。
• Hair treatment composition comprising Michael addition product and methods for treating hair
  申请人：L'OREAL

  公开号：US10004673B1

  公开（公告）日：2018-06-26

  The present disclosure relates to hair care compositions such as hair restructuring compositions comprising a combination of restructuring components. The compositions are unique because they dramatically improve the quality and durability of hair, especially chemically treated hair. Typically, the compositions include: (a) one or more amines selected from the group consisting of diamines, polyamines, alkylamines, alkanolamines, and mixtures thereof; (b) one or more unsaturated carboxylic acids of formula (I): wherein R1 is a linear or branched C2-C10 alkenyl group; R2 is a linear or branched C1-C10 alkyl group; and R3 is (meth)acryloyloxy; and (c) a cosmetically acceptable carrier.

  本公开涉及头发护理组合物，如由重组成分组合而成的头发重组组合物。这些组合物之所以独特，是因为它们能显著改善头发，尤其是经过化学处理的头发的质量和耐久性。通常，组合物包括(a) 一种或多种胺，选自由二胺、多胺、烷基胺、烷醇胺及其混合物组成的组； (b) 一种或多种式 (I) 的不饱和羧酸： 其中 R1 是直链或支链 C2-C10 烯基；R2 是直链或支链 C1-C10 烷基；R3 是（甲基）丙烯酰氧基；以及 (c) 化妆品可接受的载体。
• Compositions and methods for improving the quality of chemically treated hair
  申请人：L'OREAL

  公开号：US11135150B2

  公开（公告）日：2021-10-05

  The present disclosure relates to hair care compositions for chemically treating hair, to kits comprising the compositions, and to methods for treating hair with the compositions. The compositions include one or more polymeric acid compounds and/or polymeric acid anhydride compounds in addition to one or more active agents for chemically treating the hair. Additionally, the compositions can optionally include one or more non-polymeric, mono-, di-, and/or tri-carboxylic acids and/or one or more mono- and/or di-amines and/or polyamines. Hair treated with the compositions exhibits improved softness, smoothness, and discipline.

  本公开涉及用于化学处理头发的护发组合物、包含该组合物的试剂盒以及用该组合物处理头发的方法。除了一种或多种用于化学处理头发的活性剂外，这些组合物还包括一种或多种聚合酸化合物和/或聚合酸酐化合物。此外，组合物还可以选择性地包括一种或多种非聚合物、单羧酸、二羧酸和/或三羧酸和/或一种或多种单胺和/或二胺和/或多胺。用这些组合物处理过的头发，其柔软度、光滑度和顺滑度都会得到改善。