[2-(Tert-butylamino)-1-(furan-2-yl)-2-oxoethyl] 4-bromonaphthalene-1-carboxylate | 1353221-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [2-(Tert-butylamino)-1-(furan-2-yl)-2-oxoethyl] 4-bromonaphthalene-1-carboxylate
• 英文别名: [2-(tert-butylamino)-1-(furan-2-yl)-2-oxoethyl] 4-bromonaphthalene-1-carboxylate
• CAS: 1353221-62-1
• 化学式: C₂₁H₂₀BrNO₄
• 分子量: 430.298
• InChiKey: WTQJOHUYKIBVCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  糠醛 、 异氰酸叔丁酯 、 4-溴-1-萘甲酸 反应 0.07h， 以76%的产率得到[2-(Tert-butylamino)-1-(furan-2-yl)-2-oxoethyl] 4-bromonaphthalene-1-carboxylate
  参考文献：
  名称：

  Fast and efficient solvent-free Passerini reaction

  摘要：

  A Passerini three component condensation between a carboxylic acid, an aldehyde, and an isocyanide at high temperature under solvent-free conditions was developed. This methodology allows the formation of a broad range of alpha-acyloxyamides in excellent yields in short reaction times. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.028

文献信息

• Fast and efficient solvent-free Passerini reaction
  作者：Till Bousquet、Mouhamad Jida、Mohamad Soueidan、Rebecca Deprez-Poulain、Francine Agbossou-Niedercorn、Lydie Pelinski

  DOI：10.1016/j.tetlet.2011.11.028

  日期：2012.1

  A Passerini three component condensation between a carboxylic acid, an aldehyde, and an isocyanide at high temperature under solvent-free conditions was developed. This methodology allows the formation of a broad range of alpha-acyloxyamides in excellent yields in short reaction times. (C) 2011 Elsevier Ltd. All rights reserved.