2-Diethylamino-4,6-bis--1,3,5-triazin | 33901-81-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Diethylamino-4,6-bis--1,3,5-triazin
• 英文别名: N,N'-(6-diethylamino-[1,3,5]triazine-2,4-diyl)-bis-hydroxylamine；N~2~,N~2~-Diethyl-N~4~,N~6~-dihydroxy-1,3,5-triazine-2,4,6-triamine；N-[4-(diethylamino)-6-(hydroxyamino)-1,3,5-triazin-2-yl]hydroxylamine
• CAS: 33901-81-4
• 化学式: C₇H₁₄N₆O₂
• 分子量: 214.227
• InChiKey: RODAXCQJQDMNSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  106
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound
  申请人：——

  公开号：US20030091946A1

  公开（公告）日：2003-05-15

  A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler: 1 wherein Q is a residue that forms, together with the —N—C═N— moiety, a nitrogen-containing 6-membered ring; R A is a certain alkyl group having at least 7 carbon atoms, or -L-R 1 ; X is an aryl group; Y is a hydrogen atom, or a group capable of being split-off upon a coupling reaction; wherein, when R A is -L-R 1 , L is a divalent linking group, and R 1 is a substituent; and -L-R 1 does not represent an alkyl, alkenyl, alkynyl, or aryl group, and -L-R 1 does not represent a heterocyclic group that bonds, with a carbon atom therein, to the nitrogen atom of the nitrogen-containing 6-membered ring formed by Q and the —N—C═N— moiety.

  公式（I）的染料形成偶合剂，含有该偶合剂的银卤化物感光材料，以及从偶合剂派生的偶氮甲基染料化合物：其中Q是一个残基，与—N—C═N—基团共同形成一个含氮的6元环；RA是至少有7个碳原子的某种烷基，或-L-R1；X是芳基基团；Y是氢原子或在偶合反应中可被分离的基团；当RA是-L-R1时，L是二价连接基团，R1是取代基；且-L-R1不代表烷基、烯基、炔基或芳基基团，-L-R1也不代表含有杂环的基团，该杂环与氮含量6元环的氮原子结合在一起。
• DYE-FORMING COUPLER, SILVER HALIDE PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL, AND AZOMETHINE DYE COMPOUND
  申请人：UEHIRA Shigeki

  公开号：US20080214810A1

  公开（公告）日：2008-09-04

  A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler: wherein Q is a residue that forms, together with the —N—C═N— moiety, a nitrogen-containing 6-membered ring; R A is a certain alkyl group having at least 7 carbon atoms, or -L-R 1 ; X is an aryl group; Y is a hydrogen atom, or a group capable of being split-off upon a coupling reaction; wherein, when R A is -L-R 1 , L is a divalent linking group, and R 1 is a substituent; and -L-R 1 does not represent an alkyl, alkenyl, alkynyl, or aryl group, and -L-R 1 does not represent a heterocyclic group that bonds, with a carbon atom therein, to the nitrogen atom of the nitrogen-containing 6-membered ring formed by Q and the —N—C═N— moiety.

  公式（I）的染料形成偶合剂，含有该偶合剂的银卤化物感光材料，以及从偶合剂衍生的偶氮甲基染料化合物：其中Q是一个残基，与—N—C═N—基团一起形成含氮的6元环；RA是至少有7个碳原子的特定烷基或-L-R1；X是芳基基团；Y是氢原子或能够在偶合反应中被分离的基团；当RA是-L-R1时，L是二价连接基团，R1是取代基；-L-R1不表示烷基，烯基，炔基或芳基基团，-L-R1不表示与氮含量的6元环与Q和—N—C═N—基团形成的氮原子之间结合的杂环基团。
• Immunoassay method
  申请人：Ohzeki Katsuhisa

  公开号：US20080145869A1

  公开（公告）日：2008-06-19

  The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so as to form a complex including the object to be analyzed and Y; and measuring the labeling substance contained in the complex or the labeling substance contained in the free protein (Y), wherein the measurement of the labeling substance is performed by a chemiluminescent method which includes sensing the light generated by chemiluminescence using a photothermographic material including at least an organic silver salt, a reducing agent for silver ions and a photosensitive silver halide to form a latent image, and making the latent image visible by thermal development. An easy, quick, and highly precise immunoassay method is provided.

  本发明提供了一种免疫分析待分析物的方法，包括：在含有待分析物的样本或标本上作用第一蛋白（Y），该蛋白可以特异性地识别标本中的待分析物并被标记物质改性，以形成包括待分析物和Y的复合物；并测量复合物中包含的标记物质或自由蛋白（Y）中包含的标记物质。其中，标记物质的测量是通过化学发光法进行的，该法包括使用至少含有有机银盐、银离子还原剂和感光银卤化物的光热材料来感应化学发光所产生的光，并通过热发展使潜像可见。提供了一种简单、快速、高精度的免疫分析方法。
• Aqueous dispersion of fatty acid silver salt particles, method for redispersing fatty acid silver salt particles, photothermographic light-sensitive material, and method for producing the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0962812A1

  公开（公告）日：1999-12-08

  Fatty acid silver salt particles of an aqueous dispersion thereof which are formed by simultaneously adding into a reaction vessel (a) a silver ion-containing aqueous solution or a silver ion-containing water-organic solvent mixed solution and (b) an aqueous solution of an alkali metal salt of a fatty acid, a solution thereof in a water-organic solvent mixed solvent or a solution thereof in an organic solvent, in an amount of at least 10% of the total amount of silver to be added, and the fatty acid silver salt particles formed satisfies all the following characteristics: (1) The average equivalent-sphere diameter of the fatty acid silver salt particles is from 0.1 µm to 0.8 µm; (2) The average ratio of long sides/short sides in main planes of the fatty acid silver salt particles is from 1 to 4; (3) The average aspect ratio of the particle is from 2 to 30; and (4) The average thickness of the particles is from 0.01 µm to 0.20 µm.

  通过同时加入（a）含有银离子的水溶液或含有银离子的水-有机溶剂混合物和（b）脂肪酸的碱金属盐的水溶液，它在水-有机溶剂混合溶剂中的溶液或有机溶剂中的溶液，其添加量至少为要添加的总银量的10％，形成的水分散脂肪酸银盐颗粒，且满足以下所有特征：（1）脂肪酸银盐颗粒的平均等效球直径为0.1微米至0.8微米；（2）脂肪酸银盐颗粒主平面长边/短边的平均比率为1至4；（3）颗粒的平均纵横比为2至30；（4）颗粒的平均厚度为0.01微米至0.20微米。