N-(4-Nitro-styrylsulfonyl)-β-naphthamidin | 55978-62-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-Nitro-styrylsulfonyl)-β-naphthamidin
• 英文别名: N'-[2-(4-nitrophenyl)ethenylsulfonyl]naphthalene-2-carboximidamide
• CAS: 55978-62-6
• 化学式: C₁₉H₁₅N₃O₄S
• 分子量: 381.412
• InChiKey: CGBXEOPMELQWPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-萘羧酰胺 、 2-(4-nitrophenyl)ethenesulfonyl chloride 以affords N-(4-NITROSTYRYLSULFONYL)-β-NAPHTHAMIDINE, m.p. 180°-182.5° C.的产率得到N-(4-Nitro-styrylsulfonyl)-β-naphthamidin
  参考文献：
  名称：

  Styrylamidines

  摘要：

  Styrylamidines是通过用碱处理styrylsulfonylamidines制备的。styrylamidines有效预防血小板聚集并作为镇痛剂。该发明的化合物也可用作抗癫痫、利尿剂和降压剂。该发明的styrylsulfonylamidines是styrylamidines的前体，也具有镇痛作用。本发明的styrylamidines的实例包括4-氨基-N-(4-氨基styryl)苯胺和N-(3,4-二氯styryl)乙酰胺。styrylsulfonylamidine的例子是N-(styrylsulfonyl)乙酰胺。

  公开号：

  US04130663A1

文献信息

• Styrylamidine process
  申请人：Mead Johnson & Company

  公开号：US04206142A1

  公开（公告）日：1980-06-03

  Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

  Styrylamidines（苯乙烯基胺）是通过用碱处理苯乙烯基磺酰胺制备的。苯乙烯基胺对于防止血小板凝聚和作为止痛药是有效的。该发明的化合物也可用作抗癫痫、利尿剂和降压药。该发明的苯乙烯基磺酰胺可作为苯乙烯基胺的前体，也具有镇痛作用。该发明的苯乙烯基胺的例子包括4-氨基-N-(4-氨基苯乙烯基)苯甲酰胺和N-(3,4-二氯苯乙烯基)乙酰胺。苯乙烯基磺酰胺的例子是N-(苯乙烯基磺酰基)乙酰胺。
• Styrylamidines
  申请人：Mead Johnson & Company

  公开号：US04052455A1

  公开（公告）日：1977-10-04

  Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

  Styrylamidines是通过用碱处理styrylsulfonylamidines制备的。 Styrylamidines在预防血小板聚集和作为镇痛剂方面非常有效。 发明的化合物也可用作抗癫痫，利尿剂和降压剂。 用作前体物质制备styrylamidines的styrylsulfonylamidines也具有镇痛作用。 本发明的styrylamidines的例子包括4-氨基-N-（4-氨基苯乙烯基）苯胺和N-（3,4-二氯苯乙烯基）乙酰胺。 styrylsulfonylamidine的例子是N-（styrylsulfonyl）乙酰胺。
• Styrylsulfonylamidines
  申请人：Mead Johnson & Company

  公开号：US04096183A1

  公开（公告）日：1978-06-20

  Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

  Styrylamidines是通过用碱处理styrylsulfonylamidines制备的。styrylamidines对于预防血小板聚集和作为镇痛剂非常有效。本发明的化合物也可用作抗癫痫、利尿剂和降压剂。本发明的styrylsulfonylamidines可作为styrylamidines的前体，具有镇痛作用。本发明的styrylamidines的例子包括4-氨基-N-(4-氨基苯基)苯胺和N-(3,4-二氯苯基)乙酰胺。styrylsulfonylamidine的例子是N-(styrylsulfonyl)乙酰胺。
• FR2233988
  申请人：——

  公开号：——

  公开（公告）日：——
• Thiadiazine compound
  申请人：Mead Johnson & Company

  公开号：US04259482A1

  公开（公告）日：1981-03-31

  Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

  Styrylamidines是通过用碱处理styrylsulfonylamidines制备的。styrylamidines在预防血小板聚集和作为镇痛剂方面非常有效。本发明的化合物也可用作抗癫痫、利尿剂和降压剂。本发明的styrylsulfonylamidines作为styrylamidines的前体，也具有镇痛作用。本发明的styrylamidines的例子包括4-氨基-N-(4-氨基苯乙烯基)苯甲酰胺和N-(3,4-二氯苯乙烯基)乙酰胺。styrylsulfonylamidine的例子是N-(苯乙烯磺酰基)乙酰胺。