N-[2-[2-[3',6'-bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]ethyl-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]ethyl]amino]ethyl]-5-(dimethylamino)naphthalene-1-sulfonamide | 1005459-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-[2-[2-[3',6'-bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]ethyl-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]ethyl]amino]ethyl]-5-(dimethylamino)naphthalene-1-sulfonamide
• CAS: 1005459-65-3
• 化学式: C₅₈H₆₈N₈O₆S₂
• 分子量: 1037.36
• InChiKey: HTDQNVCXXLBWDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  74
• 可旋转键数：
  21
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  rhodamine trisamine 、 丹酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以40%的产率得到N-[2-[2-[3',6'-bis(diethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-2-yl]ethyl-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]ethyl]amino]ethyl]-5-(dimethylamino)naphthalene-1-sulfonamide
  参考文献：
  名称：

  Metal Ion Induced FRET OFF−ON in Tren/Dansyl-Appended Rhodamine

  摘要：

  A series of new fluorescent probes bearing tren-spaced rhodamine B and dansyl groups have been synthesized. Compound 1 exhibits selective changes in the absorption and the emission spectra toward Cu2+ ion over miscellaneous metal cations. Among 1-3, 1 shows the best FRET efficiency through dansyl emission to rhodamine absorption for the Cu2+ ion.

  DOI：

  10.1021/ol702558p

文献信息

• Metal Ion Induced FRET OFF−ON in Tren/Dansyl-Appended Rhodamine
  作者：Min Hee Lee、Hyun Jung Kim、Sangwoon Yoon、Noejung Park、Jong Seung Kim

  DOI：10.1021/ol702558p

  日期：2008.1.1

  A series of new fluorescent probes bearing tren-spaced rhodamine B and dansyl groups have been synthesized. Compound 1 exhibits selective changes in the absorption and the emission spectra toward Cu2+ ion over miscellaneous metal cations. Among 1-3, 1 shows the best FRET efficiency through dansyl emission to rhodamine absorption for the Cu2+ ion.