1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium | 15302-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: 1-Ethyl-1-azabicyclo[2.2.2]octan-1-ium
• 英文别名: 1-ethyl-1-azoniabicyclo[2.2.2]octane
• CAS: 15302-97-3
• 化学式: C9H18N+
• 分子量: 140.25
• InChiKey: YMOBRTJUJVJAHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Bicyclic compound, production and use thereof
  申请人：Shiraishi Mitsuru

  公开号：US20080161287A1

  公开（公告）日：2008-07-03

  The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R 1 is a 5- to 6-membered ring group which may be substituted; X 1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X 2 is a bivalent group of 1 to 4 atoms; Z 1 is a bivalent cyclic ring group or the like; Z 2 is a bond or the like; and R 2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

  本发明提供了一种具有CCR拮抗剂活性的新环状化合物，特别是CCR5拮抗剂活性，以及其用途。本发明的化合物由以下公式表示：其中，R1是一个5到6个成员的环状基团，可以被取代；X1是一个键或类似物；环A是一个5到6个成员的环状基团，可以被取代；环B是一个8到10个成员的环状基团，可以被取代；X2是1到4个原子的双价基团；Z1是一个双价的环状基团或类似物；Z2是一个键或类似物；R2是氨基、含氮杂环基团，可以被取代或类似物的盐。
• Method for manufacturing stabilized polyacetal resin, stabilized polyacetal resin, stabilized polyacetal resin composition, and molded article of stabilized polyacetal resin
  申请人：Polyplastics Co., Ltd.

  公开号：EP1867667A1

  公开（公告）日：2007-12-19

  The present invention provides an agent to decompose unstable terminal group, which is effective in a small adding amount, which sufficiently decreases the quantity of residual unstable terminal group, and which generates very little limitation on the treatment method, the apparatus, and the use amount of the agent. Specifically, it provides a method for manufacturing stabilized polyacetal resin having the step of applying heat treatment to a polyacetal resin having an unstable terminal group in the presence of an agent to decompose the unstable terminal group, which agent is composed of a heterocyclic quaternary ammonium salt, thus decreasing the quantity of the unstable terminal group.

  本发明提供了一种分解不稳定末端基团的药剂，其添加量小，效果好，能充分减少残留的不稳定末端基团的数量，并且对处理方法、装置和药剂的使用量限制很小。具体地说，它提供了一种制造稳定聚缩醛树脂的方法，该方法的步骤是：在有药剂存在的情况下，对具有不稳定末端基团的聚缩醛树脂进行热处理，以分解不稳定末端基团，该药剂由杂环季铵盐组成，从而减少不稳定末端基团的数量。
• TRANSDERMAL DELIVERY SYSTEMS OF BETA-LACTAM ANTIBIOTICS
  申请人：Yu, Chongxi

  公开号：EP3357926A1

  公开（公告）日：2018-08-08

  The novel positively charged pro-drugs of beta-lactam antibiotics in the general 'Structure 4' were designed. The positively charged amino group of the pro-drug not only makes the drugs soluble in water, but also bonds to the negative charge on the phosphate head group of membranes. This bonding will disturb the membrane a little bit and may make some room for the lipophilic portion of the prodrug. The prodrugs can be used medicinally in treating beta-lactam antibiotics-treatable conditions in humans or animals. The prodrugs can be administered transdermally for any kind of medical treatments. Controlled transdermal administration systems of the prodrug enables beta-lactam antibiotics to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of beta-lactam antibiotics.

  我们设计出了一般 "结构 4 "中的新型带正电荷的β-内酰胺类抗生素原药。原药带正电荷的氨基不仅能使药物溶于水，还能与膜上磷酸头基的负电荷结合。这种结合会稍微扰乱膜，并为原药的亲脂部分腾出一些空间。原药可用于治疗人类或动物体内可通过β-内酰胺类抗生素治疗的疾病。原药可以透皮给药，用于任何类型的医疗。原药的可控透皮给药系统可使β-内酰胺类抗生素不断达到最佳治疗血药浓度，从而提高疗效并减少β-内酰胺类抗生素的副作用。
• Method for manufacturing stabilized polyacetal resin
  申请人：Polyplastics Co., Ltd.

  公开号：EP1867667B1

  公开（公告）日：2012-10-31
• TRITERPENE QUATERNARY SALTS AS BIOLOGICALLY ACTIVE SURFACTANTS
  申请人：Krasutsky A. Pavel

  公开号：US20070088009A1

  公开（公告）日：2007-04-19

  The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.