1,4-dihydro-4-(1H-indazol-5-yl)-2,6-dimethyl-3,5-pyridinedicarbonitrile | 1033767-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1,4-dihydro-4-(1H-indazol-5-yl)-2,6-dimethyl-3,5-pyridinedicarbonitrile
• 英文别名: 4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile
• CAS: 1033767-84-8
• 化学式: C₁₆H₁₃N₅
• 分子量: 275.313
• InChiKey: BZMMZEUTUBQCMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  88.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1H-吲唑-5-甲醛 、 3-氨基巴豆腈 在 溶剂黄146 、 水 、 碳酸氢钠 作用下， 反应 1.5h， 以44%的产率得到1,4-dihydro-4-(1H-indazol-5-yl)-2,6-dimethyl-3,5-pyridinedicarbonitrile
  参考文献：
  名称：

  WO2008/71451

  摘要：

  公开号：

文献信息

• [EN] FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS DE 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMÉTHYL-1,4- DIHYDROPYRIDINE À SUBSTITUTION FLUORO ET LEURS MÉTHODES D'UTILISATION
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2011042368A1

  公开（公告）日：2011-04-14

  The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

  本发明涉及具有蛋白酪氨酸激酶抑制活性的新型氟代取代的3,5-二氰基-4-(1H-吲哚-5-基)-2,6-二甲基-1,4-二氢吡啶衍生物，以及其制备方法和用于治疗c-Met介导的疾病或c-Met介导的病况，特别是癌症和其他增生性疾病的用途。
• DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Adler Marc

  公开号：US20080176833A1

  公开（公告）日：2008-07-24

  This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.

  本发明提供了一种具有蛋白酪氨酸激酶抑制活性的新型二氢吡啶衍生物，以及其制造方法和用于治疗c-Met介导的疾病或c-Met介导的病状的用途。
• Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof
  申请人：Michels Martin

  公开号：US20120264785A1

  公开（公告）日：2012-10-18

  The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihy-dropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

  本发明涉及一种具有蛋白酪氨酸激酶抑制活性的新型氟取代的3,5-二氰基-4-(1H-吲唑-5-基)-2,6-二甲基-1,4-二氢-吡啶衍生物，以及其制造方法和用于治疗c-Met介导的疾病或c-Met介导的病状，特别是癌症和其他增殖性疾病的用途。
• Dihydropyridine derivatives as useful as protein kinase inhibitors
  申请人：Bayer Intellectual Property GmbH

  公开号：US08198456B2

  公开（公告）日：2012-06-12

  This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.

  该发明提供了具有蛋白酪氨酸激酶抑制活性的新型二氢吡啶衍生物，以及其制造方法和用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
• DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2121608B1

  公开（公告）日：2012-11-14