methyl 6-methoxy-3-methyl-1-(2-oxopropyl)-1H-indene-2-carboxylate | 1132669-70-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: methyl 6-methoxy-3-methyl-1-(2-oxopropyl)-1H-indene-2-carboxylate
• CAS: 1132669-70-5；1132669-85-2
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: OWQNCOFKNMNYNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-[5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]but-3-en-2-one 、 2-丁炔酸甲酯 在 [(DPPP)palladium(II)(H2O)2] triflate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以99%的产率得到methyl 6-methoxy-3-methyl-1-(2-oxopropyl)-1H-indene-2-carboxylate
  参考文献：
  名称：

  Cationic Palladium(II)-Catalyzed Highly Enantioselective Tandem Reactions of ortho-Boronate-Substituted Cinnamic Ketones and Internal Alkynes: A Convenient Synthesis of Optically Active Indenes

  摘要：

  Cationic palladium(II)-catalyzed tandem reactions of ortho-boronate-substituted cinnamic ketones and internal alkynes to yield optically active indenes were developed in high yields and good enantioselectivities.

  DOI：

  10.1021/ol9001015

文献信息

• Cationic Palladium(II)-Catalyzed Highly Enantioselective Tandem Reactions of <i>ortho</i>-Boronate-Substituted Cinnamic Ketones and Internal Alkynes: A Convenient Synthesis of Optically Active Indenes
  作者：Feng Zhou、Miao Yang、Xiyan Lu

  DOI：10.1021/ol9001015

  日期：2009.3.19

  Cationic palladium(II)-catalyzed tandem reactions of ortho-boronate-substituted cinnamic ketones and internal alkynes to yield optically active indenes were developed in high yields and good enantioselectivities.