methyl 2-ethyl-1,3-diphenylcycloprop-2-enecarboxylate | 1313370-62-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: methyl 2-ethyl-1,3-diphenylcycloprop-2-enecarboxylate
• 英文别名: Methyl 2-ethyl-1,3-diphenylcycloprop-2-ene-1-carboxylate；methyl 2-ethyl-1,3-diphenylcycloprop-2-ene-1-carboxylate
• CAS: 1313370-62-5
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.351
• InChiKey: LNYKOYMZNGXBEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碘苯 在 bis-triphenylphosphine-palladium(II) chloride 、 silver trifluoromethanesulfonate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.08h， 生成 methyl 2-ethyl-1,3-diphenylcycloprop-2-enecarboxylate
  参考文献：
  名称：

  Silver Triflate-Catalyzed Cyclopropenation of Internal Alkynes with Donor-/Acceptor-Substituted Diazo Compounds

  摘要：

  Silver triflate was found to be an efficient catalyst for the cyclopropenation of internal alkynes using donor-/acceptor-substituted diazo compounds as carbenoid precursors. Highly substituted cyclopropenes, which cannot be synthesized directly via rhodium(II)-catalyzed carbenoid chemistry, can now be readily accessed.

  DOI：

  10.1021/ol201503j

文献信息

• Recyclable heterogeneous metal foil-catalyzed cyclopropenation of alkynes and diazoacetates under solvent-free mechanochemical reaction conditions
  作者：Longrui Chen、Devonna Leslie、Michael G. Coleman、James Mack

  DOI：10.1039/c8sc00443a

  日期：——

  cyclopropenation of terminal and internal alkynes under mechanochemical reaction conditions. This methodology enables the functionalization of a wide range of terminal or internal alkynes under ambient, aerobic, and solvent-free conditions. Finally, we have demonstrated a unique and versatile one-pot domino Sonogashira-cyclopropenation mechanochemical reaction for the formation of complex cyclopropenes.

  发现银和铜箔是在机械化学反应条件下用于末端炔烃和内部炔烃环丙烷化的有效，通用和选择性的非均相催化剂。这种方法可以在环境，好氧和无溶剂条件下使各种末端或内部炔烃官能化。最后，我们展示了一种独特而通用的一锅多米诺多米诺Sonogashira-环丙烷化机械化学反应，用于形成复杂的环丙烯。
• Silver Triflate-Catalyzed Cyclopropenation of Internal Alkynes with Donor-/Acceptor-Substituted Diazo Compounds
  作者：John F. Briones、Huw M. L. Davies

  DOI：10.1021/ol201503j

  日期：2011.8.5

  Silver triflate was found to be an efficient catalyst for the cyclopropenation of internal alkynes using donor-/acceptor-substituted diazo compounds as carbenoid precursors. Highly substituted cyclopropenes, which cannot be synthesized directly via rhodium(II)-catalyzed carbenoid chemistry, can now be readily accessed.