1-(2-(methylthio)phenyl)-2-phenylethane-1,2-dione | 1334426-45-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2-(methylthio)phenyl)-2-phenylethane-1,2-dione
• 英文别名: 1-(2-Methylsulfanylphenyl)-2-phenylethane-1,2-dione
• CAS: 1334426-45-7
• 化学式: C₁₅H₁₂O₂S
• 分子量: 256.325
• InChiKey: SKDDTOSWVRZDCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  59.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl(2-(phenylethynyl)phenyl)sulfane 在 水 、 碳酸氢钠 、 间氯过氧苯甲酸 、 platinum(II) chloride 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 1.0h， 生成 1-(2-(methylthio)phenyl)-2-phenylethane-1,2-dione
  参考文献：
  名称：

  汞（II）催化的2-炔基苯基烷基亚砜环化提供3-酰基苯并[b]噻吩

  摘要：

  环环化：通过用氯化汞和2,3-二氯-5,6-二氰基1-4,4处理2-炔基苯基烷基亚砜，以良好的收率实现了汞催化的环化反应以提供3-苯甲酰基苯并[ b ]噻吩苯中的苯并醌（DDQ）加热回流24小时（请参阅方案）。

  DOI：

  10.1002/chem.201202704

文献信息

• α-Diketone Formation Accompanied by Oxidation of Sulfur Functional Group by the Reaction of <i>o</i>-Alkynylarenesulfoxide with Iodine
  作者：Shoji Matsumoto、Hiroyuki Shibata、Motohiro Akazome

  DOI：10.1021/jo3023186

  日期：2013.2.15

  The reaction of o-alkynylarenesulfoxide with iodine was investigated in detail, revealing functionalities of the formation of alpha-diketones with sulfenyl, sulfinyl, and sulfonyl. Additives can change the ratio of products to give medium-to-excellent yields. Results show that water is taken into only sulfonyl compound and that other oxygen atoms constructed in the products are presumably derived from sulfoxide of the starting material and molecular oxygen.
• Gold- and Iodine-Mediated Internal Oxygen Transfer of Nitrone- and Sulfoxide-Functionalized Alkynes
  作者：Dan Chen、Guoyong Song、Aiqun Jia、Xingwei Li

  DOI：10.1021/jo201347r

  日期：2011.10.21

  Intramolecular oxygen transfer of nitrone- and sulfoxide-alkynes was achieved using a catalytic amount of Au(I) and a stoichiometric amount of iodine. The Au(I)-catalyzed cyclization of a nitrone-terminal alkyne afforded a cyclic iminoester, while cyclization of analogous nitrone-internal alkynes yielded aldehyde enones. The I-2-mediated cyclization of nitrone-alkynes afforded iodinated gamma-lactams and the I-2-mediated internal redox of the closely related sulfoxide alkynes gave diketones functionalized with a thoiether.