(E)-6-ethylidene-7-hexyl-9,9-diisopropyl-2,2,3,3,10-pentamethyl-4,8-dioxa-3,9-disilaundecane | 1198582-43-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E)-6-ethylidene-7-hexyl-9,9-diisopropyl-2,2,3,3,10-pentamethyl-4,8-dioxa-3,9-disilaundecane
• 英文别名: tert-butyl-[(2E)-2-ethylidene-3-tri(propan-2-yl)silyloxynonoxy]-dimethylsilane
• CAS: 1198582-43-2
• 化学式: C₂₆H₅₆O₂Si₂
• 分子量: 456.9
• InChiKey: XKBYWBHOEGNTBX-BUVRLJJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.49
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  庚醛 、 三异丙基硅烷 、 (but-2-yn-1-yloxy)(tert-butyl)dimethylsilane 在 bis(1,5-cyclooctadiene)nickel (0) 、 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以79%的产率得到(E)-6-ethylidene-7-hexyl-9,9-diisopropyl-2,2,3,3,10-pentamethyl-4,8-dioxa-3,9-disilaundecane
  参考文献：
  名称：

  Cooperativity of Regiochemistry Control Strategies in Reductive Couplings of Propargyl Alcohols and Aldehydes

  摘要：

  The nickel-catalyzed reductive coupling of propargyl alcohols and alkynes proceeds with excellent regiochemical control with an underlying electronic preference that can be supplemented by ligand size effects. The products obtained may be readily converted to substructures that are not directly available by an aldehyde-alkyne reductive coupling. A simple model for how steric and electronic factors are both important in governing regiochemistry in couplings of this type is presented, along with examples of how the effects can combine in either a constructive or destructive manner.

  DOI：

  10.1021/ol902561r

文献信息

• Cooperativity of Regiochemistry Control Strategies in Reductive Couplings of Propargyl Alcohols and Aldehydes
  作者：Hasnain A. Malik、Mani Raj Chaulagain、John Montgomery

  DOI：10.1021/ol902561r

  日期：2009.12.17

  The nickel-catalyzed reductive coupling of propargyl alcohols and alkynes proceeds with excellent regiochemical control with an underlying electronic preference that can be supplemented by ligand size effects. The products obtained may be readily converted to substructures that are not directly available by an aldehyde-alkyne reductive coupling. A simple model for how steric and electronic factors are both important in governing regiochemistry in couplings of this type is presented, along with examples of how the effects can combine in either a constructive or destructive manner.