5,6-dichloro-3-formyl-2-(4-morpholino)pyrazine | 90601-45-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5,6-dichloro-3-formyl-2-(4-morpholino)pyrazine
• 英文别名: 5,6-Dichloro-3-(morpholin-4-yl)pyrazine-2-carbaldehyde；5,6-dichloro-3-morpholin-4-ylpyrazine-2-carbaldehyde
• CAS: 90601-45-9
• 化学式: C₉H₉Cl₂N₃O₂
• 分子量: 262.095
• InChiKey: JQPMPPJDXOYMFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,6-dichloro-3-formyl-2-(4-morpholino)pyrazine 生成 5-Chloro-3-formyl-6-((1-methylethyl)thio)-2-(4-morpholino)pyrazine
  参考文献：
  名称：

  JOHNSTON, D. B. R.

  摘要：

  DOI：
• 作为产物：
  描述：

  5,6-dichloro-3-(4-morpholino)pyrazinecarbonitrile 生成 5,6-dichloro-3-formyl-2-(4-morpholino)pyrazine
  参考文献：
  名称：

  JOHNSTON, D. B. R.

  摘要：

  DOI：

文献信息

• 3-Acyl-2-(substituted) amino-5-halo-6-(substituted) pyrazine
  申请人：Merck & Co., Inc.

  公开号：US04442097A1

  公开（公告）日：1984-04-10

  Antimicrobial compounds of the formula: ##STR1## wherein: Hal is bromine or chlorine; and R is halo; mono- or di-substituted mono- or diloweralkylamino wherein the loweralkyl substituents are hydroxy or loweralkanoyloxy; 4-morpholino; thiocyano; mercapto; straight or branched chain C.sub.1-8 alkylthio; mono- or di-substituted loweralkylthio wherein the substituents are hydroxy, amino, loweralkanoylamino, or loweralkoxycarbonyl; arylthio; loweralkylsulfoxy; or loweralkylsulfonyl; R.sup.1 is hydrogen; or loweralkyl; R.sup.2 is hydroxyloweralkyl; (CH.sub.2).sub.n COOR.sup.a, where R.sup.a is hydrogen, loweralkyl, or benzyl; and n is 1 to 3; R.sup.1 and R.sup.2 are taken together with an oxygen or nitrogen atom to form morpholino, piperazinyl, or piperazinyl which is N-loweralkyl substituted; and R.sup.3 is hydrogen; straight or branched C.sub.1-8 alkyl, provided that when R.sup.3 is hydrogen or C.sub.1-8 alkyl, R is other than halo; aryl; aryl substituted with up to two members selected from the group consisting of C.sub.1-3 alkyl, C.sub.1-3 alkoxy, halo, and mono- or di-C.sub.1-3 alkyl substituted amino; heteroaryl; formyl C.sub.2-4 alkenyl; or C.sub.2-4 alkenyl; are useful in various agricultural and industrial applications.

  该公式的抗微生物化合物为：##STR1##其中：Hal为溴或氯；R为卤素；单取代或双取代的单取代或双低碳烷氨基，其中低碳烷基取代基为羟基或低碳酰氧基；4-吗啉基；硫氰基；巯基；直链或支链C.sub.1-8烷基硫基；单取代或双取代的低碳烷基硫基，其中取代基为羟基、氨基、低碳酰胺基或低碳氧羰基；芳基硫基；低碳烷基磺氧基；或低碳烷基磺酰基；R.sup.1为氢；或低碳烷基；R.sup.2为羟基低碳烷基；(CH.sub.2).sub.n COOR.sup.a，其中R.sup.a为氢、低碳烷基或苄基；n为1至3；R.sup.1和R.sup.2结合在一起与氧或氮原子形成吗啉基、哌嗪基或N-低碳烷基取代的哌嗪基；R.sup.3为氢；直链或支链C.sub.1-8烷基，条件是当R.sup.3为氢或C.sub.1-8烷基时，R不是卤素；芳基；芳基，其上最多有两个来自由C.sub.1-3烷基、C.sub.1-3烷氧基、卤素和单取代或双取代的氨基的成员的取代基；杂环芳基；甲酰基C.sub.2-4烯基；或C.sub.2-4烯基；在各种农业和工业应用中是有用的。
• N-[(5-Halo-2,6-(substituted)pyrazinyl)methylene]amine antimicrobial
  申请人：Merck & Co., Inc.

  公开号：US04442095A1

  公开（公告）日：1984-04-10

  Antimicrobial compounds of the formula: ##STR1## wherein: Hal is bromine or chlorine; and R is halo; mono- or di-substituted mono- or diloweralkylamino wherein the loweralkyl substituents are hydroxy or loweralkanoyloxy; 4-morpholino; thiocyano; mercapto; straight or branched chain C.sub.1-8 alkylthio; mono- or di-substituted loweralkylthio wherein the substituents are hydroxy, amino, loweralkanoylamino, or loweralkoxycarbonyl; arylthio; loweralkylsulfoxy; or loweralkylsulfonyl; R.sup.1 is hydrogen; or loweralkyl; R.sup.2 is (CH.sub.2).sub.n COOR.sup.a, where R.sup.a is hydrogen, loweralkyl, or benzyl; and n is 1 to 3; R.sup.1 and R.sup.2 are taken together with an oxygen or nitrogen atom or form morpholino, piperazinyl, or piperazinyl which is N-loweralkyl substituted; R.sup.3 is hydrogen; straight or branched C.sub.1-8 alkyl; aryl; aryl substituted with up to two members selected from the group consisting of C.sub.1-3 alkyl, C.sub.1-3 alkoxy, halo, and mono- or di-C.sub.1-3 alkyl substituted amino; heteroaryl; formylC.sub.2-4 alkenyl; or C.sub.2-4 alkenyl; and R.sup.4 is straight or branched C.sub.1-8 alkyl; loweralkoxy; hydroxy; loweralkoxycarbonylmethyl; benzyl; or benzyl substituted with up to two members selected from the group consisting of halo, loweralkyl, and loweralkoxy; are useful in various agricultural and industrial applications.

  公式为：##STR1## 其中：Hal为溴或氯；R为卤素；单取代或双取代的单取代或双取代低烷基氨基，其中低烷基取代基为羟基或低烷酰氧基；4-吗啉基；硫氰基；巯基；直链或支链C.sub.1-8烷基硫基；单取代或双取代的低烷基硫基，其中取代基为羟基，氨基，低烷酰胺基或低烷氧羰基；芳基硫基；低烷基磺酰氧基；或低烷基磺酰基；R.sup.1为氢；或低烷基；R.sup.2为(CH.sub.2).sub.n COOR.sup.a，其中R.sup.a为氢，低烷基或苯甲基；n为1至3；R.sup.1和R.sup.2与氧或氮原子结合或形成吗啉基，哌嗪基或N-低烷基取代的哌嗪基；R.sup.3为氢；直链或支链C.sub.1-8烷基；芳基；芳基取代基选自C.sub.1-3烷基，C.sub.1-3烷氧基，卤素和单取代或双取代的C.sub.1-3烷基取代氨基；杂环芳基；甲酰基C.sub.2-4烯基；或C.sub.2-4烯基；R.sup.4为直链或支链C.sub.1-8烷基；低烷氧基；羟基；低烷氧羰基甲基；苯甲基；或苯甲基取代基选自卤素，低烷基和低烷氧基；在各种农业和工业应用中有用。
• JOHNSTON, D. B. R.
  作者：JOHNSTON, D. B. R.

  DOI：——

  日期：——
• US4442095A
  申请人：——

  公开号：US4442095A

  公开（公告）日：1984-04-10
• US4442097A
  申请人：——

  公开号：US4442097A

  公开（公告）日：1984-04-10