H acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: H acid
• 英文别名: 8-amino-1-naphthol-3,6-disulfonic acid disodium salt；4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid disodium salt；Sodium;4-amino-5-hydroxynaphthalene-2,7-disulfonate
• 化学式: C₁₀H₇NO₇S₂*2Na
• 分子量: 363.28
• InChiKey: QPILZZVXGUNELN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.06
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  177
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  H acid 在 palladium on activated charcoal 氢气 作用下， 以 甲苯 为溶剂， 生成 8,8'-(carbonylbis-(imino-3,1-phenylenecarbonylimino))bis-(1-naphthol-3,6-disulfonic acid) disodium salt
  参考文献：
  名称：

  Biased inhibition by a suramin analogue of A 1 -adenosine receptor/G protein coupling in fused receptor/G protein tandems: the A 1 -adenosine receptor is predominantly coupled to Go α in human brain

  摘要：

  The interface between receptors and G proteins can be considered as a drug target. Various classes of low molecular weight inhibitors have been identified that block the ability of receptors to interact with G proteins (e.g. peptides, suramin analogues and amphiphilic cations). Here we have tested if there are compounds that differentially affect the interaction of one receptor with two different (related) G protein alpha-subunits. Fusion proteins comprising the human A(1)-adenosine receptor and Galpha(i-1) (A(1)/Galpha(i-1)) or Galpha(o) (A(1)/Galpha(o)) were expressed in HEK293 cells. Suramin analogues were screened for their ability to differentially affect high affinity binding of the agonist (-)N-6-3-[I-125](iodo-4-hydroxyphenylisopropyl) adenosine (IHPIA).One compound [NF326 = 8,8'-(carbonylbis-(imino-3,1-phenylenecarbonylimino))bis-(1-naphthol-3,6-disulfonic acid. disodium salt)] was identified that inhibited high affinity agonist binding to the fusion protein A(1)/Galpha(i-1) but modestly enhanced binding of IHPIA to A(1)/Galpha(o). This action was specific because NF326 did not affect antagonist binding to either fusion protein. In addition, it was unrelated to a difference in affinity of the receptor for the G protein fusion moiety because the stability of ternary complexes formed by IHPIA + A(1)/Galpha(i-1) and IHPIA + A(1)/Galpha(o) is comparable and because lowering the affinity of the receptor for the G protein (by introducing point mutations at cys(351) of Galpha(i-1)) enhanced the uncoupling effect of NF326. Finally, NF326 did not discriminate between a fusion protein comprising the alpha(2A)-adrenoceptor and Galpha(i-1) (alpha(2A)/Galpha(i-1)) or Galpha(o-1) (alpha(2A)/Galpha(o-1)); binding of the agonist [H-3]UK14304 (bromoxidine) to both fusion proteins was inhibited over a comparable concentration range while binding of the antagonist [H-3]yohimbine was unaffected.These observations are consistent with the interpretation that the contact sites that are formed between individual receptors and G proteins differ. These differences suffice to allow for selective disruption by G protein inhibitors of different classes. Using NF326 we show that the bulk of the A(1)-adenosine receptors in human cerebrocortical membranes interacts with Galpha(o) rather than Galpha(i).

  DOI：

  10.1007/s00210-001-0493-y
• 作为产物：
  描述：

  、 1-aminonaphthalene-3,6,8-trisulphonic acid trisodium salt 在 sodium hydroxide 、 硫酸 作用下， 生成 、 disodium chromotropate 、 H acid
  参考文献：
  名称：

  一种制备H-酸的装置

  摘要：

  本发明公开了一种制备H‑酸的装置，该装置包括磺化装置、硝化装置、脱硝装置、萃取装置、还原装置、浓缩装置、稀释装置、离析和过滤装置、干燥装置，磺化装置的出口与硝化装置的进口连接，硝化装置的出口与脱硝装置的进口连接，脱硝装置的出口与萃取装置的进口连接，萃取装置的第一出口与还原装置的进口连接，还原装置的出口与浓缩装置的进口连接，浓缩装置的出口与稀释装置的进口连接，稀释装置的出口与离析和过滤装置的第一进口连接，离析和过滤装置的出口与干燥装置的进口连接，萃取装置的第二出口与离析和过滤装置的第二进口连接。该制备装置采用连续生产的方法制成H‑酸，生产效率高，节约物料，降低经济成本。

  公开号：

  CN105566171B

文献信息

• 一种微反应器内连续化制备偶氮染料的方法
  申请人：清华大学

  公开号：CN107488361B

  公开（公告）日：2019-08-16

  本发明公开了染料合成领域的一种微反应器内连续化制备偶氮染料的方法。该偶氮染料的制备是首先于常温下将亚硝酸钠溶液、芳香族伯胺、无机酸在第一个微反应器内进行重氮化反应，生成芳香族伯胺重氮盐，然后芳香族伯胺重氮盐与偶合组分在第二个微反应器内进行偶合反应，生成偶氮染料。本发明采用微反应器实现了偶氮染料的连续化制备，流程简单，反应周期短，易于对反应进程进行监测和控制；不需要加入远远过量的亚硝酸钠和偶合组分来提高反应速率，节省原料，环境友好；反应液在微反应器内实现高速碰撞混合，瞬间达到均一的反应环境，反应效率高，并且反应产物的产率及产品质量得到大幅度提高。
• Reactive dyes containing a linkage
  申请人：BASF Aktiengesellschaft

  公开号：US06359121B1

  公开（公告）日：2002-03-19

  A reactive disazo dye of the formula (I) D1—Y—D2 wherein each of D1 and D2 is a chromophore of the formula (II) in which X is fluorine, chlorine or optionally substituted pyridinium, an SO3H is present in the 5-or 6-position of the naphthalene nucleus, n is 0 or 1, and Y is a bridging group or a sulphonic acid salt of the dye of formula (I). The dyes may be used for dyeing, printing or ink-jet printing, for example, of textile materials and paper and are particularly valuable for coloring cellulosic textile materials.

  一种具有以下化学式（I）的反应性二氮酰胺染料：D1—Y—D2，其中D1和D2分别是具有以下化学式（II）的色团，其中X为氟、氯或可选择取代的吡啶基，萘环的5-位或6-位存在SO3H基团，n为0或1，Y是化学式（I）染料的桥接基团或磺酸盐。这些染料可用于染色、印刷或喷墨印刷，例如纺织材料和纸张，特别适用于着色纤维素纺织品。
• 삼반응성기를 포함하는 적색 반응성 아조염료 및 그 제조 방법
  申请人：Industry-Academic Cooperation Foundation, Dankook University 단국대학교 산학협력단(220050166344) BRN ▼106-82-12299

  公开号：KR20150025430A

  公开（公告）日：2015-03-10

  본 발명은 삼반응성기를 포함하는 신규한 화합물, 그 제조 방법 및 상기 화합물을 포함하는 적색 반응성 아조염료에 관한 것이다. 더욱 구체적으로 본 발명에 따르면, K-acid를 색소 모체로 사용함으로써 선명한 적색을 발현시킬 수 있고, 모노클로로트리아진과 2개의 β-설페이토에틸설폰기의 3개의 반응성기를 포함함으로써 기존의 이반응성기를 포함하는 반응성 염료에 비하여 셀룰로오스 섬유에 대한 고착률이 높아 생산성 향상 및 염색 폐수 절감의 효과를 갖는다.

  本发明涉及一种包含三个反应基团的新型化合物，其制备方法以及涉及含有该化合物的红色反应性偶氮染料。更具体地，根据本发明，通过将K-酸作为染料前体，可以表现出明亮的红色，并且通过包含单氯三氮和两个β-硫代乙基磺酰基的三个反应基团，相比于包含传统二反应基团的反应性染料，对纤维素纤维具有更高的吸附率，具有提高生产效率和减少染料废水的效果。
• Structure-activity relationship studies with symmetric naphthalenesulfonic acid derivatives. Synthesis and influence of spacer and naphthalenesulfonic acid moiety on anti-HIV-1 activity
  作者：Prem Mohan、Man Fai Wong、Sandeep Verma、Peggy P. Huang、Anura Wickramasinghe、Masanori Baba

  DOI：10.1021/jm00066a008

  日期：1993.7

  Symmetric bis(naphthalenesulfonic acid) derivatives containing a variety of spacers have been synthesized and evaluated for anti-HIV-1 activity in four assay systems. In the assay that measured inhibition of HIV-1-induced cytopathogenicity using a laboratory strain (HTLV-IIIB), a hexamethylene and octamethylene spacer derivative of 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid emerged as the most potent

  合成了含有多种间隔基的对称双（萘磺酸）衍生物，并在四种测定系统中评估了其抗HIV-1活性。在使用实验室菌株（HTLV-IIIB）测定对HIV-1诱导的细胞致病性抑制作用的测定中，最有效的衍生物是4-氨基-5-羟基-2,7-萘二磺酸的六亚甲基和八亚甲基间隔衍生物。六亚甲基间隔类似物的体外治疗指数> 120。在巨细胞形成试验中测试了选定的衍生物。在该测定中，最有效的衍生物还是六亚甲基化合物。针对HIV-1（HE株）的临床分离株对所选衍生物的评估表明，六亚甲基衍生物是最有效的化合物。在测定抑制人类外周血淋巴细胞中HIV-1诱导的细胞病变的实验中，六亚甲基化合物以最活跃的衍生物形式出现，显示50％的抑制浓度为1.3 microM。这些研究清楚地表明，某些萘磺酸基团与特定的间隔基偶联时，在无毒浓度下可产生抗HIV-1活性。在4-氨基-5-羟基-2，7-萘二磺酸系列中，间隔物长度的缩短，优选具有柔性聚
• Ozone Fading of 2,2′-Dihydro Azo Copper Complex Dyes
  作者：Masaki Matsui、Kenjiro Tsubota、Katsuyoshi Shibata、Hiroshige Muramatsu

  DOI：10.1246/bcsj.64.2961

  日期：1991.10

  The reactivities of dyes with ozone were in the following order, Acid Blue 74>disodium 1-(2-hydroxyphenylazo)-2-naphthol-3,6-disulfonate>Direct Yellow 12>Acid Orange 7>disodium 1-phenylazonaphthalene-3,6-disulfonate-2,2′-diolatocopper(II)>Mordant Red 3>Basic Green 4. The reaction of disodium 1-phenyl-azonaphthalene-3,6-disulfonate-2,2′-diolatocopper(II) with ozone was retarded by the introduction of electron-withdrawing groups and 8-sulfonato group. The potassium sulfonate dye was less reactive than the sodium one. Ozonization of l-phenylazonaphthalene-2,2′-diolatocopper(II) gave phenol, 2-naphthol, and phthalic anhydride.

  染料与臭氧的反应活性依次为：酸性蓝 74>1-(2-羟基苯基偶氮)-2-萘酚-3,6-二磺酸钠>直接黄 12>酸性橙 7>1-苯基偶氮萘-3,6-二磺酸钠-2,2′-二茂铁铜(II)>媒染红 3>碱性绿 4。在 1-苯基-3,6-萘二磺酸钠-2,2′-二茂铁铜(II)与臭氧的反应中，引入了缩电子基团和 8-磺酸基团，从而延缓了反应的进行。磺酸钾染料的反应性低于磺酸钠染料。臭氧氧化 l-苯基-2,2′-二茂萘铜(II)会产生苯酚、2-萘酚和邻苯二甲酸酐。