5,11,14,20-Tetrazanonacyclo[22.6.6.02,23.04,21.06,19.07,12.013,18.025,30.031,36]hexatriaconta-2,4(21),5,7(12),8,10,13(18),14,16,19,22,25,27,29,31,33,35-heptadecaene | 1243254-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 5,11,14,20-Tetrazanonacyclo[22.6.6.02,23.04,21.06,19.07,12.013,18.025,30.031,36]hexatriaconta-2,4(21),5,7(12),8,10,13(18),14,16,19,22,25,27,29,31,33,35-heptadecaene
• 英文别名: 5,11,14,20-tetrazanonacyclo[22.6.6.02,23.04,21.06,19.07,12.013,18.025,30.031,36]hexatriaconta-2,4(21),5,7(12),8,10,13(18),14,16,19,22,25,27,29,31,33,35-heptadecaene
• CAS: 1243254-93-4
• 化学式: C₃₂H₁₈N₄
• 分子量: 458.522
• InChiKey: VCRLPHUIVHUIJK-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C
• 密度：
  1.425±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis-dichlorobis(1,10-phenanthroline)ruthenium(II) dihydrate 、 5,11,14,20-Tetrazanonacyclo[22.6.6.02,23.04,21.06,19.07,12.013,18.025,30.031,36]hexatriaconta-2,4(21),5,7(12),8,10,13(18),14,16,19,22,25,27,29,31,33,35-heptadecaene 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 以69.1%的产率得到
  参考文献：
  名称：

  发光钌（II）吡啶基复合物作为DNA传递的非病毒载体

  摘要：

  两个新的发光钌（II）聚吡啶基络合物[Ru（bpy）2（tpt-phen）] Cl 2（1 ; bpy = 2,2'-联吡啶，tpt-phen = triptycenyl-1,10-phenothroline）和[ Ru（phen）2（tpt‐phen）] Cl 2（2; phen = 1,10-phenothroline）已被开发为潜在的DNA传递非病毒载体。已经研究了配合物的光物理和电化学性质，并通过电子结构计算得到了证实。这些配合物的DNA缩合已通过UV / Vis和发射光谱，圆二色光谱，原子力显微镜，动态光散射，共聚焦显微镜和电泳迁移率研究进行了研究。这些复合物与DNA相互作用，并有效地将DNA凝聚成球形纳米颗粒，这些颗粒被HeLa细胞有效吸收。已经研究了复合物的DNA切割能力和生物相容性。两种复合物均具有良好的基因转染能力。

  DOI：

  10.1002/asia.201601515
• 作为产物：
  描述：

  2,3-diaminotriptycene 、 1,10-邻二氮杂菲-5,6-二酮 以 甲醇 为溶剂， 以67%的产率得到5,11,14,20-Tetrazanonacyclo[22.6.6.02,23.04,21.06,19.07,12.013,18.025,30.031,36]hexatriaconta-2,4(21),5,7(12),8,10,13(18),14,16,19,22,25,27,29,31,33,35-heptadecaene
  参考文献：
  名称：

  Synthesis and Structures of 1,10-Phenanthroline-Based Extended Triptycene Derivatives

  摘要：

  通过¹H NMR、¹³C NMR、MALDI-TOF MS 光谱和元素分析确定了它们的结构。

  DOI：

  10.1055/s-0029-1219957

文献信息

• Synthesis and Structures of 1,10-Phenanthroline-Based Extended Triptycene Derivatives
  作者：Chuan-Feng Chen、Yi Jiang

  DOI：10.1055/s-0029-1219957

  日期：2010.7

  A series of novel 1,10-phenanthroline-based extended triptycene derivatives were conveniently synthesized in good yields, and their structures were determined by ¹H NMR, ¹³C NMR, MALDI-TOF MS spectra, and elemental analysis.

  通过¹H NMR、¹³C NMR、MALDI-TOF MS 光谱和元素分析确定了它们的结构。
• Efficient DNA condensation by ruthenium(<scp>ii</scp>) polypyridyl complexes containing triptycenyl functionalized 1,10-phenanthroline
  作者：Satish S. Bhat、Vidyanand K. Revankar、Rahul V. Pinjari、Naveen S、Chetana Bogar、Kishor Bhat、Vitthal A. Kawade

  DOI：10.1039/c7nj00738h

  日期：——

  series of luminescent ruthenium(II) polypyridyl complexes containing an extended aromatic moiety derived from triptycene and 1,10-phenanthroline were synthesized and their photophysical, theoretical, and biological properties were investigated. These complexes rapidly condense DNA into nano-aggregates at room temperature. The DNA interactions and DNA condensation properties of these complexes were investigated

  合成了一系列发光的钌（II）聚吡啶基配合物，这些配合物包含一个由三茂铁和1,10-菲咯啉衍生的扩展芳族部分，并研究了它们的光物理，理论和生物学特性。这些复合物在室温下迅速将DNA浓缩成纳米聚集体。通过吸收和发射光谱，电泳迁移率测定和原子力显微镜研究了这些复合物的DNA相互作用和DNA缩合性质。它们的DNA切割活性和复合物的低毒性满足了良好的非病毒基因递送载体的要求。
• Molecular Scaffolding of Prussian Blue Analogues Using a Phenanthroline-Extended Triptycene Ligand
  作者：Xavier Roy、Jonathan H. Chong、Brian O. Patrick、Mark J. MacLachlan

  DOI：10.1021/cg200788f

  日期：2011.10.5

  Shape-persistent ligands with triptycene groups are promising candidates for the development of porous metal-organic frameworks with functional surface area. In this work, a series of phenanthroline-extended triptycene compounds was synthesized and used as structure-directing ligands for the fabrication of a triptycene-scaffolded Prussian blue analogue. The ligands were reacted with K(3)[Fe(CN)(6)] and CuCl(2) under hydrothermal conditions to afford two new clathrates: a coordination compound of (triptycenyl phenanthroline) copper(I) and an infinite one-dimensional zigzag coordination polymer of copper cyanide scaffolded by phenanthroline-extended triptycenes. These structures illustrate the potential for the triptycene-functionalized ligands to provide access to materials with interesting architectures.
• Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery
  作者：Satish S. Bhat、Vidyanand K. Revankar、Ayesha Khan、Rahul V. Pinjari、Marek Necas

  DOI：10.1002/asia.201601515

  日期：2017.1.17

  Two new luminescent ruthenium(II) polypyridyl complexes, [Ru(bpy)2(tpt‐phen)]Cl2 (1; bpy=2,2′‐bipyridine, tpt‐phen=triptycenyl‐1,10‐phenanthroline) and [Ru(phen)2(tpt‐phen)]Cl2 (2; phen=1,10‐phenanthroline), have been developed as potential nonviral vectors for DNA delivery. Photophysical and electrochemical properties of the complexes have been investigated and corroborated with electronic structure

  两个新的发光钌（II）聚吡啶基络合物[Ru（bpy）2（tpt-phen）] Cl 2（1 ; bpy = 2,2'-联吡啶，tpt-phen = triptycenyl-1,10-phenothroline）和[ Ru（phen）2（tpt‐phen）] Cl 2（2; phen = 1,10-phenothroline）已被开发为潜在的DNA传递非病毒载体。已经研究了配合物的光物理和电化学性质，并通过电子结构计算得到了证实。这些配合物的DNA缩合已通过UV / Vis和发射光谱，圆二色光谱，原子力显微镜，动态光散射，共聚焦显微镜和电泳迁移率研究进行了研究。这些复合物与DNA相互作用，并有效地将DNA凝聚成球形纳米颗粒，这些颗粒被HeLa细胞有效吸收。已经研究了复合物的DNA切割能力和生物相容性。两种复合物均具有良好的基因转染能力。