8-benzoylamino-3-[(2S)-3-(4,4'-dimethoxytrityloxy)-2-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxy]-propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine | 1187577-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 8-benzoylamino-3-[(2S)-3-(4,4'-dimethoxytrityloxy)-2-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxy]-propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
• 英文别名: N-[4-[(2S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]-2,4,6,11,13-pentazatricyclo[7.4.0.03,7]trideca-1,3(7),5,8,10,12-hexaen-10-yl]benzamide
• CAS: 1187577-45-2
• 化学式: C₄₈H₅₁N₈O₆P
• 分子量: 866.957
• InChiKey: SJIMWKMDLMXAIX-NISZCSPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  63
• 可旋转键数：
  20
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (9ci)-5-氨基-1H-咪唑并[4,5-b]吡啶-6-甲腈 在 吡啶 、 咪唑 、 四丁基氟化铵 、 potassium carbonate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 183.5h， 生成 8-benzoylamino-3-[(2S)-3-(4,4'-dimethoxytrityloxy)-2-[[(2-cyanoethoxy)(N,N-diisopropylamino)phosphanyl]oxy]-propyl]imidazo[4',5':5,6]pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

  摘要：

  The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we developed a novel method for SNP detection. We designed and synthesized DNA probes containing a fluorescent tricyclic base-linked acyclonucleoside P. The type of nucleobases involved in the SNP sites in the DNA and RNA targets could be determined using four DNA probes containing P. Thus, this system would provide a novel and simple method for detecting SNPs in DNA and RNA targets. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.045

文献信息

• RNA-SELECTIVE HYBRIDIZATION REAGENT AND USE OF THE SAME
  申请人：Ueno Yoshihito

  公开号：US20110033863A1

  公开（公告）日：2011-02-10

  Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R 1 represents a hydrogen atom or a hydroxyl-protecting group; and R 2 represents a hydrogen atom or a phosphodiester group).

  提供了一种对RNA具有高亲和力的核苷衍生物。使用的是由公式(1)或公式(2)所表示的核苷衍生物。（在公式(1)和(2)中，Z代表碳原子或氮原子；R1代表氢原子或羟基保护基；R2代表氢原子或磷酸二酯基团）。
• Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms
  作者：Kinji Furukawa、Mayumi Hattori、Tokimitsu Ohki、Yoshiaki Kitamura、Yukio Kitade、Yoshihito Ueno

  DOI：10.1016/j.bmc.2011.11.045

  日期：2012.1

  The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we developed a novel method for SNP detection. We designed and synthesized DNA probes containing a fluorescent tricyclic base-linked acyclonucleoside P. The type of nucleobases involved in the SNP sites in the DNA and RNA targets could be determined using four DNA probes containing P. Thus, this system would provide a novel and simple method for detecting SNPs in DNA and RNA targets. (C) 2011 Elsevier Ltd. All rights reserved.