2-hexylthietane | 740834-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环丁烷
• 英文名称: 2-hexylthietane
• 英文别名: 2-Hexylthietane
• CAS: 740834-58-6
• 化学式: C₉H₁₈S
• 分子量: 158.308
• InChiKey: YMZGDPPTWRYAIR-UHFFFAOYSA-N

物化性质

• 沸点：
  214.8±8.0 °C(Predicted)
• 密度：
  0.909±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-hexylthietane 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以83%的产率得到2-hexylthietane 1,1-dioxide
  参考文献：
  名称：

  Synthesis of 2-alkyl(aryl)thietanes

  摘要：

  Thietane and its 2-substituted derivatives were synthesized. A general preparation procedure for the synthesis of thietanes bearing alkyl and aryl substituents in the (x-position was developed. Using this procedure, 2-substituted thietanes can be obtained from cheap and easily accessible raw materials in three steps. 2-R-Thietanes (where R = H, CH3, C4H9,C5H11,C6H13,C6H5) and the corresponding sulfoxides and sulfones were synthesized and examined. Intermediate and by-products of the synthesis were studied.

  DOI：

  10.1134/s0965544107020089
• 作为产物：
  描述：

  3-chloro-1-methoxynonane 在 三溴化磷 、 potassium hydrosulfide 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 2-hexylthietane
  参考文献：
  名称：

  Synthesis of 2-alkyl(aryl)thietanes

  摘要：

  Thietane and its 2-substituted derivatives were synthesized. A general preparation procedure for the synthesis of thietanes bearing alkyl and aryl substituents in the (x-position was developed. Using this procedure, 2-substituted thietanes can be obtained from cheap and easily accessible raw materials in three steps. 2-R-Thietanes (where R = H, CH3, C4H9,C5H11,C6H13,C6H5) and the corresponding sulfoxides and sulfones were synthesized and examined. Intermediate and by-products of the synthesis were studied.

  DOI：

  10.1134/s0965544107020089

文献信息

• Facile synthesis of thietanes via ring expansion of thiiranes
  作者：Jun Dong、Jiaxi Xu

  DOI：10.1039/c6ob02387h

  日期：——

  Thietanes are pharmaceutically important cores of some biological compounds and intermediates of organic synthesis. Various thietanes were prepared from thiiranes via ring expansion through a reaction with trimethyloxosulfonium iodide in the presence of sodium hydride. The reaction process is a nucleophilic ring-opening reaction of thiiranes with dimethyloxosulfonium methylide, generated from trimethyloxosulfonium

  硫杂环丁烷是某些生物化合物和有机合成中间体的药学上重要的核心。在氢化钠的存在下，通过与三甲基氧through碘化物的反应，通过环扩张从硫烷制备各种硫杂环丁烷。该反应过程是由三甲基氧ulf碘化物和氢化钠产生的硫烷与二甲基氧os甲基亚砜的亲核开环反应，随后是硫醇盐的分子内置换（环化）反应生成二甲基氧os部分。当前的方法提供了一种从容易获得的硫烷有效制备硫杂环丁烷的新策略。
• The Rh(II) catalyzed reaction of diethyl diazomalonate with thietanes: a facile synthesis of tetrahydrothiophene derivatives via sulfonium ylides
  作者：Vijay Nair、Smitha M. Nair、Sindhu Mathai、Jürgen Liebscher、Burkhard Ziemer、K. Narsimulu

  DOI：10.1016/j.tetlet.2004.05.062

  日期：2004.7

  A facile Rh(II) catalyzed reaction of diethyl diazomalonate with thietanes leading to highly substituted tetrahydrothiophenes along with allyl thioethers is described.

  描述了重氮丙二酸二乙酯与硫杂环丁烷的容易的Rh（II）催化反应，导致烯丙基硫醚与高度取代的四氢噻吩。
• An efficient synthesis of isothiazolidines via sulfonium ylides formed by the reaction of thietanes and nitrene
  作者：Vijay Nair、Smitha M. Nair、S. Devipriya、D. Sethumadhavan

  DOI：10.1016/j.tetlet.2005.12.024

  日期：2006.2

  An efficient synthesis of isothiazolidines in good yields is described.

  描述了高产率的异噻唑烷的有效合成。
• Synthesis of 2-alkyl(aryl)thietanes
  作者：N. P. Volynskii、S. E. Shevchenko

  DOI：10.1134/s0965544107020089

  日期：2007.3

  Thietane and its 2-substituted derivatives were synthesized. A general preparation procedure for the synthesis of thietanes bearing alkyl and aryl substituents in the (x-position was developed. Using this procedure, 2-substituted thietanes can be obtained from cheap and easily accessible raw materials in three steps. 2-R-Thietanes (where R = H, CH3, C4H9,C5H11,C6H13,C6H5) and the corresponding sulfoxides and sulfones were synthesized and examined. Intermediate and by-products of the synthesis were studied.