5-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]-1,3-dihydrobenzimidazole-2-thione | 958264-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]-1,3-dihydrobenzimidazole-2-thione
• CAS: 958264-71-6
• 化学式: C₂₁H₂₆N₄O₂S
• 分子量: 398.529
• InChiKey: FUSUKSWNUZIJFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二硫化碳 、 4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]benzene-1,2-diamine 在 氢氧化钾 作用下， 以53%的产率得到5-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]-1,3-dihydrobenzimidazole-2-thione
  参考文献：
  名称：

  Two new phenylpiperazines with atypical antipsychotic potential

  摘要：

  Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.066

文献信息

• Two new phenylpiperazines with atypical antipsychotic potential
  作者：Mirko Tomić、Djurdjica Ignjatović、Gordana Tovilović、Deana Andrić、Goran Roglić、Sladjana Kostić-Rajačić

  DOI：10.1016/j.bmcl.2007.08.066

  日期：2007.11

  Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.