6,7-dichloro-2-methyl-3-propylquinoxaline | 219528-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dichloro-2-methyl-3-propylquinoxaline
• CAS: 219528-43-5
• 化学式: C₁₂H₁₂Cl₂N₂
• 分子量: 255.147
• InChiKey: PUOLIAVPVWVRRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-nitro-hexan-3-ol 在 双氧水 、 甲基磺酰氯 、 N,N-二异丙基乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 40.17h， 生成 6,7-dichloro-2-methyl-3-propylquinoxaline
  参考文献：
  名称：

  Nitroepoxides as Versatile Precursors to 1,4-Diamino Heterocycles

  摘要：

  Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.

  DOI：

  10.1021/ol500444z

文献信息

• Green and Efficient Synthesis of Quinoxaline Derivatives via Ceric Ammonium Nitrate Promoted and in Situ Aerobic Oxidation of .ALPHA.-Hydroxy Ketones and .ALPHA.-Keto Oximes in Aqueous Media
  作者：Ahmad Shaabani、Ali Maleki

  DOI：10.1248/cpb.56.79

  日期：——

  The direct conversion of alpha-hydroxy ketones and alpha-keto oximes into quinoxaline derivatives in the presence of a catalytic amount of ceric ammonium nitrate via metal-catalyzed aerobic oxidation followed by in situ trapping with aromatic 1,2-diamines in water as a green and efficient reaction media, is reported.

  在催化量的硝酸铈铵存在下，通过金属催化的需氧氧化，将α-羟基酮和α-酮肟直接转化为喹喔啉衍生物，然后在水中将芳族1,2-二胺原位捕集为绿色高效反应介质的报道。
• Nitroepoxides as Versatile Precursors to 1,4-Diamino Heterocycles
  作者：Andreu Vidal-Albalat、Santiago Rodríguez、Florenci V. González

  DOI：10.1021/ol500444z

  日期：2014.3.21

  Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.