2-[4-(2,4-difluoro-phenyl)-piperazin-1-yl]-N-(3,4-dimethoxy-phenyl)-acetamide | 1197347-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(2,4-difluoro-phenyl)-piperazin-1-yl]-N-(3,4-dimethoxy-phenyl)-acetamide
• 英文别名: Benzamide derivative, 14e；2-[4-(2,4-difluorophenyl)piperazin-1-yl]-N-(3,4-dimethoxyphenyl)acetamide
• CAS: 1197347-60-6
• 化学式: C₂₀H₂₃F₂N₃O₃
• 分子量: 391.418
• InChiKey: KSKFCSUNSBSRNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氯-N-(3,4-二甲氧基苯基)-乙酰胺 、 1-(2,4-二氟苯基)哌嗪 在 potassium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以69%的产率得到2-[4-(2,4-difluoro-phenyl)-piperazin-1-yl]-N-(3,4-dimethoxy-phenyl)-acetamide
  参考文献：
  名称：

  Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase

  摘要：

  A series of benzamide derivatives which can simultaneously inhibit glycogen phosphorylase (GP) and activate glucokinase (GK) were prepared and evaluated. The structure-activity relationships (SAR) of these compounds were also presented. Among these, compounds 12, 13l, 13q, and 13v showed moderate activities towards both GK and GP. Compound 13h inhibited hLGP with an IC50 of 8.95 mu M and activated GK with an EC50 of 1.87 mu M. The possible binding modes of compounds 12, 13l, 13h, and 13q with GP and GK were also explored by molecular docking simulation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.045

文献信息

• [EN] PHENYLPIPERAZINE DERIVATIVE<br/>[FR] DÉRIVÉ PHÉNYLPIPÉRAZINE
  申请人：SUMITOMO DAINIPPON PHARMA CO LTD

  公开号：WO2014192865A1

  公开（公告）日：2014-12-04

  本発明は、式（１）［式中、Ｚ１はハロゲン原子、アルキル基等を表し；Ｒ１１～Ｒ２５は水素原子、ハロゲン原子、アルキル基等を表し；Ｘ２は、ハロゲン原子を表す］で表される化合物もしくはそれらの薬学上許容される塩などを有効成分とする神経変性疾患および精神疾患の治療薬に関する。
• Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase
  作者：Lei Zhang、Honglin Li、Qingzhang Zhu、Jun Liu、Ling Chen、Ying Leng、Hualiang Jiang、Hong Liu

  DOI：10.1016/j.bmc.2009.08.045

  日期：2009.10

  A series of benzamide derivatives which can simultaneously inhibit glycogen phosphorylase (GP) and activate glucokinase (GK) were prepared and evaluated. The structure-activity relationships (SAR) of these compounds were also presented. Among these, compounds 12, 13l, 13q, and 13v showed moderate activities towards both GK and GP. Compound 13h inhibited hLGP with an IC50 of 8.95 mu M and activated GK with an EC50 of 1.87 mu M. The possible binding modes of compounds 12, 13l, 13h, and 13q with GP and GK were also explored by molecular docking simulation. (C) 2009 Elsevier Ltd. All rights reserved.