(R)-(+)-2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate | 1147699-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (R)-(+)-2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate
• 英文别名: 2-(4-benzhydrylpiperazin-1-yl)ethyl (4R)-5-cyclopentyloxy-2-methyl-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-1,6-naphthyridine-3-carboxylate
• CAS: 1147699-74-8
• 化学式: C₄₁H₄₃F₃N₄O₃
• 分子量: 696.813
• InChiKey: QIODKNQMXXGSCJ-BHVANESWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  51
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate 以 甲醇 、 异丙胺 为溶剂， 以99%的产率得到
  参考文献：
  名称：

  [EN] 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES
  [FR] DÉRIVÉS DE 1,4-DIHYDRONAPHTYRIDINE

  摘要：

  一种化合物的公式（I）或该化合物的前药或其药用可接受的盐或前药，其中取代基如规范中所定义，含有该化合物的药用组合物可用作钙通道拮抗剂，并用于治疗心脏病和疼痛的方法。

  公开号：

  WO2009056934A1

文献信息

• USES, COMPOSITIONS AND METHODS
  申请人：Fisahn Andre

  公开号：US20210038589A1

  公开（公告）日：2021-02-11

  The present invention relates generally to calcium channel inhibitors for use in treating and/or preventing an amyloid disease of the nervous system. The invention also relates to related pharmaceutical compositions, kits and screening methods.
• T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF
  申请人：Praxis Precision Medicines, inc.

  公开号：US20210128537A1

  公开（公告）日：2021-05-06

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.
• [EN] T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DE CANAL CALCIQUE DE TYPE T ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PRAXIS PREC MEDICINES INC

  公开号：WO2018118101A1

  公开（公告）日：2018-06-28

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.
• [EN] 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 1,4-DIHYDRONAPHTYRIDINE
  申请人：PFIZER PROD INC

  公开号：WO2009056934A1

  公开（公告）日：2009-05-07

  A compound of formulae (I) or a prodrug of the compound or a pharmaceutically acceptable salt thereof of the compound or prodrug, wherein the substituents are as defined in the specification, pharmaceutical compositions containing the compounds useful as calcium channel antagonists, and to methods of treating heart disease and pain.

  一种化合物的公式（I）或该化合物的前药或其药用可接受的盐或前药，其中取代基如规范中所定义，含有该化合物的药用组合物可用作钙通道拮抗剂，并用于治疗心脏病和疼痛的方法。