(R)-(+)-2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate | 1147699-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (R)-(+)-2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate
• 英文别名: 2-(4-benzhydrylpiperazin-1-yl)ethyl (4R)-5-cyclopentyloxy-2-methyl-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-1,6-naphthyridine-3-carboxylate
• CAS: 1147699-74-8
• 化学式: C₄₁H₄₃F₃N₄O₃
• 分子量: 696.813
• InChiKey: QIODKNQMXXGSCJ-BHVANESWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  51
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-(4-benzhydrylpiperazin-1-yl)ethyl 5-(cyclopentyloxy)-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,6-naphthyridine-3-carboxylate 以 甲醇 、 异丙胺 为溶剂， 以99%的产率得到
  参考文献：
  名称：

  [EN] 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES
  [FR] DÉRIVÉS DE 1,4-DIHYDRONAPHTYRIDINE

  摘要：

  一种化合物的公式（I）或该化合物的前药或其药用可接受的盐或前药，其中取代基如规范中所定义，含有该化合物的药用组合物可用作钙通道拮抗剂，并用于治疗心脏病和疼痛的方法。

  公开号：

  WO2009056934A1

文献信息

• USES, COMPOSITIONS AND METHODS
  申请人：Fisahn Andre

  公开号：US20210038589A1

  公开（公告）日：2021-02-11

  The present invention relates generally to calcium channel inhibitors for use in treating and/or preventing an amyloid disease of the nervous system. The invention also relates to related pharmaceutical compositions, kits and screening methods.
• T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF
  申请人：Praxis Precision Medicines, inc.

  公开号：US20210128537A1

  公开（公告）日：2021-05-06

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.
• [EN] T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DE CANAL CALCIQUE DE TYPE T ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PRAXIS PREC MEDICINES INC

  公开号：WO2018118101A1

  公开（公告）日：2018-06-28

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.