7-(1-Naphthalen-1-ylethenyl)spiro[1,2,4-trioxepane-3,2'-adamantane] | 1019360-57-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-(1-Naphthalen-1-ylethenyl)spiro[1,2,4-trioxepane-3,2'-adamantane]
• CAS: 1019360-57-6
• 化学式: C₂₅H₂₈O₃
• 分子量: 376.496
• InChiKey: BUQFPFKPCXMZKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-hydroperoxy-4-(1-naphthyl)pent-4-en-1-ol 、 金刚烷酮 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以7%的产率得到7-(1-Naphthalen-1-ylethenyl)spiro[1,2,4-trioxepane-3,2'-adamantane]
  参考文献：
  名称：

  Orally active 1,2,4-trioxepanes: Synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice☆

  摘要：

  7-Arylvinyl-1,2,4-trioxepanes 7a-d, 8a-d, 9a-d, 10a-d, 11a-c, and 12a-c, prepared by photooxygenation of homoallylic alcohols 5a-d, were evaluated against multi-drug resistant Plasmodium yoelii nigeriensis in Swiss mice by oral and intramuscular routes. Trioxepane 11c, the most active compound of the series, showed more than 98% suppression of parsitaemia at 96 mg/kg by both oral and intramuscular routes. This is the first report on in vivo active 1,2,4-trioxepanes. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.11.012

文献信息

• Orally active 1,2,4-trioxepanes: Synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice☆
  作者：Chandan Singh、Shilpi Pandey、Malvika Sharma、Sunil K. Puri

  DOI：10.1016/j.bmc.2007.11.012

  日期：2008.2.15

  7-Arylvinyl-1,2,4-trioxepanes 7a-d, 8a-d, 9a-d, 10a-d, 11a-c, and 12a-c, prepared by photooxygenation of homoallylic alcohols 5a-d, were evaluated against multi-drug resistant Plasmodium yoelii nigeriensis in Swiss mice by oral and intramuscular routes. Trioxepane 11c, the most active compound of the series, showed more than 98% suppression of parsitaemia at 96 mg/kg by both oral and intramuscular routes. This is the first report on in vivo active 1,2,4-trioxepanes. (C) 2007 Elsevier Ltd. All rights reserved.