naphthalene-2-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide | 1365658-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalene-2-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide
• 英文别名: naphthalene-2-sulfonic acid (2-fluoro-4-hydroxylphenyl)amide；naphthalen-2-sulfonic acid (2-fluoro-4-hydroxyphenyl)amide；N-(2-fluoro-4-hydroxyphenyl)naphthalene-2-sulfonamide
• CAS: 1365658-26-9
• 化学式: C₁₆H₁₂FNO₃S
• 分子量: 317.341
• InChiKey: KKPONFYGALYAJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氨基-3-氟苯酚 、 2-萘磺酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以30%的产率得到naphthalene-2-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide
  参考文献：
  名称：

  小分子磺酰胺在软骨分化和关节软骨修复中的潜在治疗应用

  摘要：

  关节软骨受损的修复是再生医学的长期目标。间充质干细胞（MSCs）的软骨细胞特异性分化可能是修复受损软骨的有效手段。我们确定了磺酰胺作为促进人脂肪来源的MSC（hASCs）的特定软骨分化的试剂的小分子6。与其他由各种定义成分组成的软骨分化培养基不同，在本研究中，仅将化合物6添加到培养基中就足以诱导软骨形成。在动物骨关节炎模型中，小分子6和6经治疗的hASC显示出受损的关节软骨恢复增强。这项工作为小分子诱导的MSC分化提供了新的见识，并为关节软骨损伤提供了潜在的新治疗方法。

  DOI：

  10.1016/j.bmcl.2016.08.069

文献信息

• PHARMACEUTICAL COMPOSITION WITH ENHANCED EFFICACY FOR INHIBITING ANGIOGENESIS
  申请人：Kwon Ho Jeong

  公开号：US20140315947A1

  公开（公告）日：2014-10-23

  The present invention relates to a pharmaceutical composition for inhibiting angiogenesis and a novel sulfonyl amide derivative compound which can be useful for the prevention or treatment of angiogenesis-related diseases or disorders. Since the compound used as an active ingredient in the pharmaceutical composition of the invention is specifically bound to UQCRB and inhibits biological functions thereof, apoptosis is not induced and angiogenic responses are inhibited. Therefore, the compound used as an active ingredient in the pharmaceutical composition of the invention can be useful as an effective and safe angiogenesis inhibitory agent.

  本发明涉及一种用于抑制血管生成的药物组合物以及一种新型磺酰胺衍生物化合物，该化合物可用于预防或治疗与血管生成相关的疾病或疾病。由于本发明药物组合物中所使用的活性成分化合物特异地结合到UQCRB并抑制其生物功能，不会诱导凋亡并抑制血管生成反应。因此，本发明药物组合物中所使用的活性成分化合物可以作为一种有效且安全的抑制血管生成的药剂。
• USE OF A COMPOUND FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS INTO CARTILAGE CELLS
  申请人：Catholic Kwandong University Industry Foundation

  公开号：EP2617415B1

  公开（公告）日：2016-04-20
• Use of a Compound for Inducing Differentiation of Mesenchymal Stem Cells into Cartilage Cells
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：US20150252003A1

  公开（公告）日：2015-09-10

  Use of a compound of Formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of Formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of Formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect.
• US9371286B2
  申请人：——

  公开号：US9371286B2

  公开（公告）日：2016-06-21
• [EN] USE OF A COMPOUND FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS INTO CARTILAGE CELLS<br/>[FR] UTILISATION D'UN COMPOSÉ PERMETTANT D'INDUIRE LA DIFFÉRENCIATION DE CELLULES SOUCHES MÉSENCHYMATEUSES EN CELLULES DE CARTILAGE
  申请人：UNIV YONSEI IACF

  公开号：WO2012036512A2

  公开（公告）日：2012-03-22

  본 발명은 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화학식 1의 화합물의 용도 및 화학식 1의 화합물에 의해 중간엽 줄기세포로부터 분화 유도된 연골 세포를 포함하는 연골질환 치료용 의약 조성물을 제공한다. 화학식 1의 화합물로 처리된 중간엽 줄기세포는 연골 세포로 특이적으로 분화 유도되므로 이를 이용하면 관절염, 연골 손상, 연골 결손 등의 연골 질환을 효과적으로 치료할 수 있게 된다.