N'-(4-methoxyphenyl)sulfonyl-N'-methylnaphthalene-2-sulfonohydrazide | 104685-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N'-(4-methoxyphenyl)sulfonyl-N'-methylnaphthalene-2-sulfonohydrazide
• CAS: 104685-39-4
• 化学式: C₁₈H₁₈N₂O₅S₂
• 分子量: 406.483
• InChiKey: BINGWBLJYYEFLJ-UHFFFAOYSA-N

物化性质

• 熔点：
  187-189 °C
• 沸点：
  597.1±52.0 °C(Predicted)
• 密度：
  1.394±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲基肼 生成 N'-(4-methoxyphenyl)sulfonyl-N'-methylnaphthalene-2-sulfonohydrazide
  参考文献：
  名称：

  SARTORELLI, ALAN C.;SHYAM, KRISHNAMURTHY

  摘要：

  DOI：

文献信息

• 1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity
  作者：Krishnamurthy Shyam、Robert T. Hrubiec、Ryosuke Furubayashi、Lucille A. Cosby、Alan C. Sartorelli

  DOI：10.1021/jm00394a040

  日期：1987.11

  A series of 1,2-bis(sulfonyl)hydrazines was synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active agent to emerge from this study, 1,2-bis(methylsulfonyl)-1-methylhydrazine, produced a maximum % T/C for mice bearing the L1210 leukemia or the B16 melanoma of 340% and 278%, respectively. Two N-chloroethyl analogues, conceived as bifunctional alkylating agents, were also synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. Although such a modification resulted in retention of antineoplastic activity against both tumor cell lines, it did not result in enhanced antineoplastic activity.
• SARTORELLI, ALAN C.;SHYAM, KRISHNAMURTHY
  作者：SARTORELLI, ALAN C.、SHYAM, KRISHNAMURTHY

  DOI：——

  日期：——
• SHYAM, KRISHNAMURTHY;HRUBIEC, ROBERT T.;FURUBAYASHI, RYOSUKE;COSBY, LUCIL+, J. MED. CHEM., 30,(1987) N 11, 2157-2161
  作者：SHYAM, KRISHNAMURTHY、HRUBIEC, ROBERT T.、FURUBAYASHI, RYOSUKE、COSBY, LUCIL+

  DOI：——

  日期：——