Ethylphosphonsaeure-ethoxycarbonylmethylester-ethylester | 117898-78-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Ethylphosphonsaeure-ethoxycarbonylmethylester-ethylester
• 英文别名: Ethyl 2-[ethoxy(ethyl)phosphoryl]oxyacetate
• CAS: 117898-78-9
• 化学式: C₈H₁₇O₅P
• 分子量: 224.194
• InChiKey: FDOCUMITGXDAKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙基磷酸二乙酯 、 溴乙酸乙酯 生成 Ethylphosphonsaeure-ethoxycarbonylmethylester-ethylester
  参考文献：
  名称：

  Pudovik,A.N. et al., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2606 - 2612

  摘要：

  DOI：

文献信息

• Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof
  申请人：——

  公开号：US20020123509A1

  公开（公告）日：2002-09-05

  The present application relates to new carboxylic acid amides of general formula 1 wherein A, B and R 1 to R 3 are defined as in claim 1, processes for preparing them, pharmaceutical compositions containing these compounds and the use thereof and their preparation.

  本申请涉及一般式1的新羧酸酰胺，其中A、B和R1至R3的定义如权利要求1所述，制备它们的方法，含有这些化合物的制药组合物以及它们的用途和制备方法。
• Bicyclooctane derivatives, processes for producing them, pharmaceutical compositions containing them, their use as pharmaceuticals and precursors thereof
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0036730A2

  公开（公告）日：1981-09-30

  Certain novel bicyclooctanes and their pharmaceutically acceptable salts are useful in the treatment of gastrointestinal ulcers. These compounds can be prepared by various methods and have the formula wherein X1 is a free or esterified carboxyl group, a hydroxymethyl group, a cyano group, a group of the formula: (Ra and Rb are each independently a hydrogen atom, a C1-C4 alkyl group, a C3-C7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C1-C4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7-membered saturated heterocyclic group) or a group of the formula: (Ra and Rb are each as defined above), Y is an ethylene group or a vinylene group, R1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R2 is a hydrogen atom or R1 and R2, when taken together, means a single linkage to form a double bond between the carbon atoms which they are linked, R3 is a hydroxyl group or a protected hydroxyl group, R4 is a hydrogen atom or a C1-C4 alkyl group, R5 is a hydrogen atom, a C3-C8 alkenyl group, a C3-C8 alkynyl group, a C1-C8 alkyl group, a C3-C7 cycloalkyl group or a group of the formula: -(CH2)n-B (n is 1 or 2 and B is a C1-C4 alkoxyl group, a C3-C7 cycloalkyl group, or a phenyl or phenoxy group optionally substituted with a halogen atom, a C1-C4 alkyl group, a trifluoromethyl group or a C1-C4 alkoxyl group), A is a group of either one of the formulae: -CH=CH-, (R6 and R7 are each independently a hydrogen atom or a C1-C4 alkyl group) and m1 is 1 or 2 and m2 is 0, 1 or 2.

  某些新型双环辛烷及其药学上可接受的盐类可用于治疗胃肠道溃疡。这些化合物可通过各种方法制备，其式如下 其中 X1 是游离的或酯化的羧基、羟甲基、氰基、式中的基团： (Ra和Rb各自独立地为氢原子、C1-C4烷基、C3-C7环烷基、苄基、苯基、被卤素原子或C1-C4烷基取代的苯基，或当它们与相邻的氮原子连接在一起时，它们代表5-7元饱和杂环基）或式中的基团： (Ra和Rb各自如上定义），Y是乙烯基或乙烯基，R1是氢原子、羟基或受保护的羟基，R2是氢原子，或 R1和R2连在一起时，表示在它们所连接的碳原子之间形成双键的单链、R3 是羟基或受保护的羟基，R4 是氢原子或 C1-C4 烷基，R5 是氢原子、C3-C8 烯基、C3-C8 炔基、C1-C8 烷基、C3-C7 环烷基或式中的一个基团：-(CH2)n-B（n 为 1 或 2，B 为 C1-C4 烷氧基、C3-C7 环烷基或任选被卤素原子、C1-C4 烷基、三氟甲基或 C1-C4 烷氧基取代的苯基或苯氧基），A 为以下式中任一式的基团：-CH=CH-、 (R6和R7各自独立地为氢原子或C1-C4烷基），m1为1或2，m2为0、1或2。
• Novel cinnamoylamide derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0291247A2

  公开（公告）日：1988-11-17

  A cinnamoylamide derivative of general formula: wherein, (i) when R² represents a methyl group and R³ represents a hydrogen atom, (R¹)n represents a 3-pentyl, 4-pentyl, 4-neopentyl, 4-(2-ethylbutyl), 4-(2-methylpentyl), 2-fluoro-4-pentyloxy, 4-butylthio, 4-cyclobutylmethyl, 4-cyclohexylmethyl, 4-(4-phenylbutyl) or 4-phenoxy, and (ii) when R² represents a hydrogen atom and R³ represents a methyl group, (R¹)n represents 3-pentyl or 4-phenethyl] and non-toxic salts thereof possess inhibitory activity on 5α-reductase, indicative of utility for treating and/or preventing alopecia, acne or prostatic hypertrophy.

  通式如下的肉桂酰胺衍生物 其中 (i) 当 R² 代表甲基且 R³ 代表氢原子时、 (R¹)n代表3-戊基、4-戊基、4-新戊基、4-(2-乙基丁基)、4-(2-甲基戊基)、2-氟-4-戊氧基、4-丁硫基、4-环丁基甲基、4-环己基甲基、4-(4-苯基丁基)或4-苯氧基，以及 (ii) 当 R² 代表氢原子且 R³ 代表甲基时、 (R¹)n代表3-戊基或4-苯乙基]及其无毒盐具有抑制5α-还原酶的活性，可用于治疗和/或预防脱发、痤疮或前列腺肥大。
• Process for the preparation of a segmented thermoplastic elastomer
  申请人：AKZO N.V.

  公开号：EP0013461B1

  公开（公告）日：1983-04-06
• Polyester-ester urethane
  申请人：AKZO N.V.

  公开号：EP0102115B1

  公开（公告）日：1987-06-10