2-甲基-1,4-萘亚基二(硫酸氢酯) | 29520-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-甲基-1,4-萘亚基二(硫酸氢酯)
• 英文名称: 2-methyl-1,4-bis-sulfooxy-naphthalene
• 英文别名: (2-Methyl-naphthalindiyl-(1.4))-bis-hydrogensulfat；(2-Methyl-naphthylen-(1.4))-bis-hydrogensulfat；2-Methyl-1,4-bis-sulfooxy-naphthalin；1.4-Disulfooxy-2-methyl-naphthalin；Menadiol disulfate；(2-methyl-4-sulfooxynaphthalen-1-yl) hydrogen sulfate
• CAS: 29520-22-7
• 化学式: C₁₁H₁₀O₈S₂
• 分子量: 334.328
• InChiKey: JYJGXBHAXCGVHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  144
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,4-二羟基-2-甲基萘 在 吡啶 、 四氯化碳 、 chlorosulphuric acid 作用下， 生成 2-甲基-1,4-萘亚基二(硫酸氢酯)
  参考文献：
  名称：

  Water-Soluble Antihemorrhagic Esters

  摘要：

  DOI：

  10.1021/ja01858a504

文献信息

• Solvent systems for pharmaceutical agents
  申请人：——

  公开号：US20020102280A1

  公开（公告）日：2002-08-01

  The invention provides compositions, solvent systems, and methods for solubilizing compounds which are otherwise difficult to solubilize. The invention involves the use of a structured fluid (e.g. a liquid crystalline phase, an L1 phase, an L2 phase, an L3 phase, an emulsion, or a microemulsion), comprising a polar solvent, a lipid or a surfactant, and an essential oil or a dissolution/solubilization agent.

  这项发明提供了用于溶解那些通常难以溶解的化合物的组合物、溶剂系统和方法。该发明涉及使用结构化流体（例如液晶相、L1相、L2相、L3相、乳化液或微乳化液），其中包括极性溶剂、脂质或表面活性剂以及精油或溶解/溶解剂。
• METHODS OF INCREASING THE EXPRESSION YIELD OF VITAMIN K-DEPENDENT PROTEINS
  申请人：Keane Julian

  公开号：US20120322107A1

  公开（公告）日：2012-12-20

  The invention encompasses the use of one or more compounds selected from a list comprising i) reduced forms of vitamin K and/or ii) reduced forms of a vitamin K analog and/or iii) reduced forms of a vitamin K precursor for the expression of one or more functional vitamin K-dependent proteins in cell culture as well as processes for the fermentation of eucaryotic cells expressing one or more vitamin K-dependent proteins wherein one or more compounds selected from a list comprising i) reduced forms of vitamin K and/or ii) reduced forms of a vitamin K analog and/or iii) reduced forms of a vitamin K precursor are added to the cell culture medium before and/or during the fermentation process.

  该发明涵盖了从以下列表中选择的一种或多种化合物的使用，包括i）维生素K的还原形式和/或ii）维生素K类似物的还原形式和/或iii）维生素K前体的还原形式，用于在细胞培养中表达一种或多种功能性维生素K依赖性蛋白质，以及用于发酵表达一种或多种维生素K依赖性蛋白质的真核细胞的过程，在这些过程中，在发酵过程之前和/或期间向细胞培养基中添加从以下列表中选择的一种或多种化合物，包括i）维生素K的还原形式和/或ii）维生素K类似物的还原形式和/或iii）维生素K前体的还原形式。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Drug releasing coatings for medical devices
  申请人：Lutonix, Inc.

  公开号：EP2092941A2

  公开（公告）日：2009-08-26

  The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

  本发明涉及一种向组织输送治疗剂的医疗器械。该医疗器械的外表面覆盖有一层。该层含有治疗剂和添加剂。添加剂有亲水部分和疏水部分，治疗剂不包裹在胶束中，也不封装在颗粒或控释载体中。
• Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
  申请人：Lutonix, Inc.

  公开号：EP2500044A2

  公开（公告）日：2012-09-19

  The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.

  本发明涉及一种可在数秒至数分钟内向组织快速输送治疗剂的涂层医疗器械。该医疗器械的外表面覆盖有一层涂层。该层含有治疗剂、造影剂和添加剂。