Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis
Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis
Adamantan Derivate, 4. Mitt.: Unerwartete Debenzylierung bei der Cyclisierung von 1-(1-Adamantylcarbonyl)-4-benzylthiosemicarbazid mit Schwefels�ure
作者:A. A. El-Emam、J. Lehmann
DOI:10.1007/bf00811852
日期:1994.5
Cyclization of 1-(1-adamantylcarbonyl)-4-substituted thiosemicarbazides 2a-e with sulphuric acid at ambient temperature or by heating with phosphorus oxychloride yielded the corresponding 2-(1-adamantyl)-5-amino-1,3,4-thiadiazoles 3a-e. Cyclization of 1-(1-adamantylcarbonyl)-4-benzylthiosemicarbazide 2f with sulphuric acid gave the debenzylated product 2-(1-adamantyl)-5-amino-1,3,4-thiadiazole 4. On the other hand, cyclization of 2f using phosphorus oxychloride yielded 2-(1-adamantyl)-5-benzylamino-1,3,4-thiadiazole 3f.
Quantitative assessment of the nature of noncovalent interactions in <i>N</i>-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis
作者:Ali A. El-Emam、Elangovan Saveeth Kumar、Krishnakumar Janani、Lamya H. Al-Wahaibi、Olivier Blacque、Mohamed I. El-Awady、Nora H. Al-Shaalan、M. Judith Percino、Subbiah Thamotharan
DOI:10.1039/d0ra00733a
日期:——
The nature and strength of various noncovalent interactions in three adamantane derivatives are characterized using QTAIM approach.