(1R,2R)-1-amino-2-aminomethylcyclohexane | 26853-49-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2R)-1-amino-2-aminomethylcyclohexane
• 英文别名: (1R,2R)-2-(aminomethyl)cyclohexylamine；rac-cis-1-aminomethyl-2-aminocyclohexane；(1R,2R)-2-(aminomethyl)cyclohexan-1-amine
• CAS: 26853-49-6
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: ZUYYQGFCSKJGDO-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trisodium hexanitrocobaltate(III) 、 (1R,2R)-1-amino-2-aminomethylcyclohexane 在 盐酸 作用下， 以 水 为溶剂， 生成 trans-bis[(1R,2R)-2-(aminomethyl)cyclohexylamine]dichlorocobalt(III) chloride
  参考文献：
  名称：

  Tris[(1R,2R)-或(1R,2S)-2-(氨基甲基)环己胺]钴(III)配合物的制备和结构研究

  摘要：

  已合成含有 (1R,2R)- 或 (1R,2S)-2-(氨基甲基) 环己胺 (=amcha) 的新型钴 (III) 配合物并将其分离为非对映异构体。[Co(1R,2R-amcha)3]3+ 得到两种非对映异构体，根据它们的 13C-NMR 和 CD 光谱推断其结构为 mer-Δ 和 fac-Δ。[Co(1R,2S-amcha)3]3+ 产生三种非对映异构体，其结构被确定为mer-Λ、mer-Δ和fac-Λ。在不存在或存在硫酸根离子的情况下研究了六元螯合环的构象。

  DOI：

  10.1246/bcsj.58.1279
• 作为产物：
  描述：

  (1R,2S)-2-aminocyclohexanecarbonitrile 在 lithium aluminium tetrahydride 作用下， 生成 cis 2-(aminomethyl)cyclohexylamine 、 (1R,2R)-1-amino-2-aminomethylcyclohexane
  参考文献：
  名称：

  An effective approach to the enantiomers of alicyclic β-aminonitriles by using lipase catalysis

  摘要：

  Lipase-catalyzed N-acylations of racemic cis- and trans-2-aminocyclopentane- (and cyclohexane-) carbonitriles with 2,2,2-trifluoethyl butanoate in tert-butyl methyl ether (TBME) and in room-temperature ionic liquids (RTILs) were studied. The racemates were effectively resolved (E > 200) on a preparative scale by lipase PS-C II (lipase from Burkholderia cepacia) in TBME, resulting in two enantiomers in their enantiopure forms at 50% conversion. The reactions in RTILs with Novozym 435 (Candida antarctica lipase B) were slow and proceeded with low enantio selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.10.017

文献信息

• (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
  申请人：Schering AG

  公开号：US20030194371A1

  公开（公告）日：2003-10-16

  The invention relates to (ethylene)-(propylene)-triaminepentaacetic acid derivatives that are substituted on both the ethylene bridge and the propylene bridge, as well as conjugates of these compounds with biomolecules. The compounds and conjugates are suitable as agents for NMR diagnosis and radiodiagnosis as well as for radiotherapy.

  该发明涉及在乙烯桥和丙烯桥上取代的(乙烯)-(丙烯)-三胺五乙酸衍生物，以及这些化合物与生物分子的结合物。这些化合物和结合物适用于核磁共振诊断和放射诊断代理，以及放射治疗。
• Platinum (IV) complexes
  申请人：Kidani, Yoshinori

  公开号：EP0237450A2

  公开（公告）日：1987-09-16

  New platinum (IV) complexes are now provided, which exhibit antitumor activity as shown by the tests on mouse leukemia, L-1210 cell in mice. These new platinum (IV) complexes contain, 1,2-cyclohexanediamine or 2-(aminomethyl)cylclohexyl-amine as a ligand.

  通过对小鼠白血病 L-1210 细胞的测试，发现新的铂（IV）络合物具有抗肿瘤活性。这些新的铂（IV）配合物含有 1,2-环己二胺或 2-（氨基甲基）环己胺作为配体。
• Novel platinum-steroid complexes
  申请人：Kidani, Yoshinori

  公开号：EP0265350A1

  公开（公告）日：1988-04-27

  Novel platinum(II)-steroid complexes are now provided, which exhibit antitumor activities as shown by tests on mouse leukemia, L-1210 cells in mice. These novel platinum(II)-steroid complexes contain a 1,2-cyclohexanediamine, a 2-(aminomethyl)cyclohexylamine, an ethylenediamine or NH₃- groups as a ligand or ligands.

  这些新型铂(II)-类固醇配合物含有 1,2-环己二胺、2-(氨基甲基)环己胺、乙二胺或 NH₃-基团作为配体。
• (Ethylene)-( propylene)-triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
  申请人：——

  公开号：US20040258620A1

  公开（公告）日：2004-12-23

  The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.

  本发明涉及一类新型配体、由此类配体和金属离子组成的络合物，以及这些金属络合物和大分子的加合物。本发明还描述了配体-金属络合物的药物组合物及制造和使用方法。本发明还涉及使用大分子加合物增强诊断成像。特别是，本发明涉及(乙烯)-(丙烯)-三胺五乙酸(EPTPA)衍生物、其生产工艺及其用于生产核磁共振诊断或放射诊断或放射治疗的药剂。
• Platinum complexes, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments
  申请人：Kidani, Yoshinori

  公开号：EP0008936B1

  公开（公告）日：1983-02-16