2-甲基-2,3,4,5-四氢-1,5-苯并硫氮杂卓 | 19197-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 中文名称: 2-甲基-2,3,4,5-四氢-1,5-苯并硫氮杂卓
• 英文名称: 2-Methyl-2,3,4,5-tetrahydro-1,5-benzothiazepine
• 英文别名: 2-Methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin；2,3,4,5-Tetrahydro-2-methyl-1,5-benzothiepin；2,3,4,5-Tetrahydro-2-methyl-1,5-benzothiazepin；2-methyl-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepine
• CAS: 19197-44-5
• 化学式: C₁₀H₁₃NS
• mdl: MFCD06655138
• 分子量: 179.286
• InChiKey: ONDQDOJJBDXTPY-UHFFFAOYSA-N

物化性质

• 沸点：
  115-120 °C(Press: 0.25 Torr)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

文献信息

• Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US10702521B2

  公开（公告）日：2020-07-07

  The present invention relates to methods for treating Neisseria Gonorrhoeae infection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or pharmaceutically acceptable salts thereof and/or corresponding pharmaceutical compositions.

  本发明涉及治疗淋病双球菌感染的方法，包括向需要的受试者施用新型1,2-二氢-2a,5,8a-三氮杂蒽-3,8-二酮化合物：或其药学上可接受的盐和/或相应的药物组合物。
• Method for treating gonorrhea with (2R)-2-({4-[(3,4-dihydro-2H-pyrano[2,3-C]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2A,5,8A-triazaacenaphthylene-3,8-dione
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US11229646B2

  公开（公告）日：2022-01-25

  The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.

  本发明涉及治疗淋病奈瑟菌感染的方法，其中包括向有需要的受试者施用本文所述的新型三环含氮化合物和相应的药物组合物。
• TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US20170304301A1

  公开（公告）日：2017-10-26

  The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.