2-amino-1-phenylethanol | 4388-18-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-1-phenylethanol
• 英文别名: 2,2'-((2-hydroxy-2-phenylethyl)azanediyl)bis(ethan-1-ol)；alpha-[[bis(2-hydroxyethyl)amino]methyl]benzenemethanol；2-[bis(2-hydroxyethyl)amino]-1-phenyl-1-ethanol；2-bis(2-hydroxyethyl)amino-1-phenyl-1-ethanol；2-phenyltriethanolamine；bis-(2-hydroxy-ethyl)-(β-hydroxy-phenethyl)-amine；Bis(2-hydroxyethyl)(2-phenyl-2-hydroxyethyl)amine；2-[bis(2-hydroxyethyl)amino]-1-phenylethanol
• CAS: 4388-18-5
• 化学式: C₁₂H₁₉NO₃
• mdl: MFCD05269385
• 分子量: 225.288
• InChiKey: LSAHHRKFQFEJPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-amino-1-phenylethanol 以79%的产率得到
  参考文献：
  名称：

  LUKEVITS EH. YA.; ZELCHAN G. I.; BARTON T. D.; LAPSINYA A. F.; YUDEJKA I.+, LATVRRS ZINATNU AKAD. VESTIS KIM. SER., IZV. AN LATVSSR. CEP. XIM., 1978,+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-1-苯乙醇 、 二乙醇胺 在 potassium carbonate 作用下， 以 乙醇 、 xylene 为溶剂， 生成 2-amino-1-phenylethanol
  参考文献：
  名称：

  Daoud; Osman; Karrar, Pharmazie, 1988, vol. 43, # 7, p. 470 - 472

  摘要：

  DOI：

文献信息

• Synthesis of new titanatranes containing organic substituents in the atrane fragment
  作者：K. V. Zaitsev、S. S. Karlov、M. V. Zabalov、A. V. Churakov、G. S. Zaitseva、D. A. Lemenovskii

  DOI：10.1007/s11172-006-0197-z

  日期：2005.12

  Titanatrane CpTi(OCH(CH3)CH2)3N (3) was prepared by the reaction of CpTiCl3 with N(CH2CH(CH3)OH)3 in the presence of triethylamine. The reaction of CpTi(OMe)3 (8) with N(CH2CH2OH)2(CH2CHPhOH), erythro-N(CH2CH2OH)2(CHPhCHPhOH), and N(CH2CH2OH)2(CH2CPh2OH) gave cyclopentadienyltitanatranes 12–14. Compound 8 reacts with threo-N(CH2CH2OH)2(CHPhCHPhOH) to give a mixture of threo-CpTi(OCH2CH2)2(OCHPhCHPh)N and threo-MeOTi(OCH2CH2)2(OCHPhCHPh)N. Slow hydrolysis of the latter product gave threo-[Ti3O(OMe)(OCH2CH2)2− (OCHPhCHPh)N} 3]2, which was studied by X-ray diffraction analysis. The crystal structures of 3 and 12 were also determined by X-ray diffraction analysis. The titanium coordination polyhedron in these complexes is a distorted trigonal bipyramid in which the equatorial positions are occupied by three oxygen atoms and the axial positions contain the N atom and the Cp group. The titanium—nitrogen distances (2.313(2), 2.291(2) Å in two independent molecules of 3 and 2.271(2) Å in compound 12) confirm the presence of Ti←N transannular interaction.

  合成了钛酸胺 CpTi(OCH(CH3)CH2)3N (3)，反应物为 CpTiCl3 和 N(CH2CH(CH3)OH)3，在三乙胺存在下进行反应。CpTi(OMe)3 (8) 与 N(CH2CH2OH)2(CH2CHPhOH)、erythro-N(CH2CH2OH)2(CHPhCHPhOH) 和 N(CH2CH2OH)2(CH2CPh2OH) 反应，得到环戊二烯基钛酸胺 12–14。化合物 8 与 threo-N(CH2CH2OH)2(CHPhCHPhOH) 反应生成 threo-CpTi(OCH2CH2)2(OCHPhCHPh)N 和 threo-MeOTi(OCH2CH2)2(OCHPhCHPh)N 的混合物。后者产品的缓慢水解得到 threo-[Ti3O(OMe)(OCH2CH2)2−(OCHPhCHPh)N} 3]2，采用 X 射线衍射分析进行研究。化合物 3 和 12 的晶体结构也通过 X 射线衍射分析进行测定。这些配合物中钛的配位多面体为扭曲的三角双锥，赤道位置被三个氧原子占据，轴向位置则包含了氮原子和 Cp 基团。钛—氮距离（在两个独立的 3 分子中分别为 2.313(2)、2.291(2) Å，化合物 12 中为 2.271(2) Å）证实了存在 Ti←N 跨环相互作用。
• Synthesis and characterization of metallatranes with phenyl substituents in atrane cage
  作者：Sergey S. Karlov、Anastasia A. Selina、Eleonora S. Chernyshova、Yuri F. Oprunenko、Alexei A. Merkulov、Victor A. Tafeenko、Andrei V. Churakov、Judith A.K. Howard、Galina S. Zaitseva

  DOI：10.1016/j.ica.2006.07.109

  日期：2007.2

  N(CH2CH2O)2(CHR3CR1R2O)MZ (M = Si, Z = CH2Cl, C CPh, H, OMenth, R1, R2, R3 = H, Ph; M = B, Z = nothing, R1, R2, R3 = H, Ph) have been synthesized. Both transalkoxylation and stepwise modification of a preformed metallatrane skeleton were used. The chloromethyl derivatives N(CH2CH2O)2(CHRCHRO)SiCH2Cl (R = H, Ph) react with tert-BuOK under intramolecular cycle expansion to give 1-tert-butoxy-2-carba-3-oxahomosilatranes

  摘要一系列新的单和二苯基取代的甲硅烷基和硼烷烃N（CH2CH2O）2（CHR3CR1R2O）MZ（M = Si，Z = CH2Cl，C CPh，H，OMenth，R1，R2，R3 = H，Ph; M = B ，Z ＝无，R 1，R 2，R 3 ＝ H，Ph）已经合成。既进行了烷氧基化反应又对预先形成的金属latrane骨架进行了逐步修饰。氯甲基衍生物N（CH2CH2O）2（CHRCHRO）SiCH2Cl（R = H，Ph）在分子内循环膨胀下与叔丁基醚反应，得到1-叔丁氧基-2-氨基-3-氧杂亚杂环戊酸酯N（CH2CH2O）（CH2CH2OCH2） （CHRCHRO）SiOtBu（R = H，Ph）。用三氟甲磺酸和三氟甲磺酸三甲基甲硅烷基酯处理硼烷烃N（CH2CH2O）2（CH2CR1R2O）B（R1，R2 = H，Ph）会导致氮原子上发生亲电进攻的产物。
• ETCHANT COMPOSITION, METHOD OF ETCHING INSULATING FILM, METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE, AND SILANE COMPOUND
  申请人：SK Innovation Co., Ltd.

  公开号：US20190359887A1

  公开（公告）日：2019-11-28

  An etchant composition includes a silane compound represented by the following Chemical Formula 1: wherein R 1 to R 6 are independently hydrogen, halogen, a substituted or unsubstituted C 1 -C 20 hydrocarbyl group, a phenyl group, a C 1 -C 20 alkoxy group, a carboxy group, a carbonyl group, a nitro group, a tri (C 1 -C 20 ) alkylsilyl group, a phosphoryl group, or a cyano group, L is a direct bond or C 1 -C 3 hydrocarbylene, A is an n-valent radical, and n is an integer of 1 to 4.

  一种蚀刻组合物包括以下化学式1所代表的硅烷化合物：其中R1至R6独立地表示氢、卤素、取代或未取代的C1-C20烃基、苯基、C1-C20烷氧基、羧基、羰基、硝基、三(C1-C20)烷基硅基、磷酰基或氰基，L是直接键或C1-C3烃基亚基，A是n价基团，n为1至4的整数。
• Morpholine compounds
  申请人：Beecham Group p.l.c.

  公开号：US04914202A1

  公开（公告）日：1990-04-03

  A method for inceasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal survival rate of livestock comprises the administration to livestock of an effective, non-toxic amount of a compound of formula (I), or a veterinarily acceptable acid addition salt thereof: ##STR1## wherein R.sup.1 is phenyl (C.sub.1-6)alkyl or optionally substituted C.sub.1-6 alkyl, and W is optionally substituted phenyl, a heterocyclyl group, or phenoxymethyl optionally substituted on the phenyl group. Certain compounds of formula (I) are novel.

  一种增加家畜体重增加和/或提高饲料利用效率和/或增加瘦体重和/或降低出生死亡率和增加产后存活率的方法，包括向家畜施用公式（I）的有效、无毒量的化合物或其兽医可接受的酸加成盐：##STR1## 其中R.sup.1是苯基（C.sub.1-6）烷基或可选择取代的C.sub.1-6烷基，W是可选择取代的苯基、杂环基或在苯基上可选择取代的苯氧甲基。公式（I）的某些化合物是新颖的。
• Highly selective synthesis of novel (<i>E</i>)-styrylsilatranes via ruthenium-catalyzed <i>trans</i>-silylation
  作者：Bogna Sztorch、Dawid Frąckowiak、Bogdan Marciniec

  DOI：10.1080/00397911.2018.1532519

  日期：2018.12.2

  Abstract Protocols for the synthesis of cage-substituted 1-vinylsilatranes have been developed and updated. The 1-vinylsilatranes with organic substituents attached to silatrane cage were functionalized in ruthenium-catalyzed trans-silylation with olefins, leading to novel styrylsilatranes in high yields. Graphical Abstract

  摘要 笼取代的 1-乙烯基硅油烷的合成方案已得到开发和更新。将有机取代基连接到 silatrane 笼上的 1-乙烯基硅杂环在钌催化的与烯烃的甲硅烷基转移中官能化，从而以高产率获得新型苯乙烯基杂环糊精。图形概要