Decan-4-yloxy-ethynyl-di(propan-2-yl)silane

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Decan-4-yloxy-ethynyl-di(propan-2-yl)silane
• 英文别名: decan-4-yloxy-ethynyl-di(propan-2-yl)silane
• 化学式: C₁₉H₃₆N₃OPolSi
• 分子量: 296.6
• InChiKey: SAAWZPVPEASQBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.08
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Decan-4-yloxy-ethynyl-di(propan-2-yl)silane 在 氟化氢吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 L-薄荷醇
  参考文献：
  名称：

  Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker

  摘要：

  A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports In a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-CI) as a functionalized protecting group linker.

  DOI：

  10.1021/ol100968t
• 作为产物：
  描述：

  EDIPS-Cl 、 4-正癸醇 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以65%的产率得到Decan-4-yloxy-ethynyl-di(propan-2-yl)silane
  参考文献：
  名称：

  Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker

  摘要：

  A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports In a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-CI) as a functionalized protecting group linker.

  DOI：

  10.1021/ol100968t

文献信息

• Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker
  作者：Pallavi Sharma、John E. Moses

  DOI：10.1021/ol100968t

  日期：2010.6.18

  A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports In a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-CI) as a functionalized protecting group linker.