tert-butyl 1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperidine-1-carboxylate | 223535-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperidine-1-carboxylate
• 英文别名: tert-butyl 1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperdine-1-carboxylate；tert-Butyl-1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperidine-1-carboxylate；tert-butyl 4-[1-(4-methoxycarbonylphenyl)piperidin-4-yl]piperidine-1-carboxylate
• CAS: 223535-60-2
• 化学式: C₂₃H₃₄N₂O₄
• 分子量: 402.534
• InChiKey: JDQGBFFBIJVSEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperidine-1-carboxylate 在 氢氧化钾 、 乙醇 、 盐酸 作用下， 以 水 为溶剂， 反应 1.0h， 生成 4-[1'-(tert-butoxycarbonyl)-4,4'-bipiperidin-1-yl]benzoic acid
  参考文献：
  名称：

  WO2008/85316

  摘要：

  公开号：
• 作为产物：
  描述：

  对溴苯甲酸甲酯 、 N-boc-4,4-联哌啶 在 palladium diacetate 、 2-二苯基磷-2'-(N,N-二甲氨基)联苯 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 tert-butyl 1'-[4-(methoxycarbonyl)phenyl]-4,4'-bipiperidine-1-carboxylate
  参考文献：
  名称：

  WO2008/85316

  摘要：

  公开号：

文献信息

• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100029688A1

  公开（公告）日：2010-02-04

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物是G蛋白偶联受体GPR-119的激动剂。
• ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100075987A1

  公开（公告）日：2010-03-25

  Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式子为(I)的双哌啶类化合物，用于治疗或预防2型糖尿病和类似疾病。同时包括药用可接受的盐和溶剂。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。
• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：WOOD HAROLD B.

  公开号：US20120178681A1

  公开（公告）日：2012-07-12

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。
• Acyl bipiperidinyl compounds useful as GPR 119 agonists
  申请人：Wood Harold B.

  公开号：US08399485B2

  公开（公告）日：2013-03-19

  Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了化合物(I)的Bipiperidyl，可用于治疗或预防2型糖尿病和类似疾病。还包括药学上可接受的盐和溶剂化物。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。
• Bipiperidinyl compounds, compositions, containing such compounds and methods of treatment
  申请人：Wood Harold B.

  公开号：US08445499B2

  公开（公告）日：2013-05-21

  Bipiperidinyl compounds of the formula: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式子如下的双哌啶化合物，用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂化合物也包括在内。这些化合物是G蛋白偶联受体GPR-119的激动剂。