N,N-dimethyl 3-methoxythiophene amide | 512188-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: N,N-dimethyl 3-methoxythiophene amide
• 英文别名: 3-methoxy-N,N-dimethylthiophene-2-carboxamide
• CAS: 512188-17-9
• 化学式: C₈H₁₁NO₂S
• 分子量: 185.247
• InChiKey: CWVURBUAVUHBMK-UHFFFAOYSA-N

物化性质

• 沸点：
  327.3±27.0 °C(Predicted)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl 3-methoxythiophene amide 在 硫酸 、 硝酸 作用下， 反应 1.0h， 以65%的产率得到3-methoxy-N,N-dimethyl-5-nitrothiophene-2-carboxamide
  参考文献：
  名称：

  Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres

  摘要：

  Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald protocol are the key elements of the synthetic approach. The hydroxy thiophene-containing compounds displayed good binding inhibitions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.085
• 作为产物：
  描述：

  3-methoxy-2-thenoyl chloride 、 二甲胺 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 N,N-dimethyl 3-methoxythiophene amide
  参考文献：
  名称：

  Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres

  摘要：

  Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald protocol are the key elements of the synthetic approach. The hydroxy thiophene-containing compounds displayed good binding inhibitions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.085

文献信息

• 3,4-Di-substituted maleimide compounds as CXC chemokine receptor antagonists
  申请人：Schering Corporation

  公开号：US20040034229A1

  公开（公告）日：2004-02-19

  Disclosed are compounds of the formula (I) 1 or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

  公开的是公式（I）的化合物，或其药学上可接受的盐或溶剂。这些化合物可用于治疗由趋化因子介导的疾病，如急性和慢性炎症性疾病和癌症。
• 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
  申请人：SCHERING CORPORATION

  公开号：US20040063709A1

  公开（公告）日：2004-04-01

  Disclosed compounds of the formula (I) 1 or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

  公开的化合物式(I)1或其药学上可接受的盐或溶剂，这些化合物可用于治疗由趋化因子介导的疾病，如急性和慢性炎症性疾病和癌症。
• 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
  申请人：Taveras Arthur G.

  公开号：US06903131B2

  公开（公告）日：2005-06-07

  Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

  本发明揭示了化合物I式或其药学上可接受的盐或溶剂，该化合物对于治疗由趋化因子介导的疾病，如急性和慢性炎症性疾病和癌症，具有用途。
• US6878709B2
  申请人：——

  公开号：US6878709B2

  公开（公告）日：2005-04-12
• US6903131B2
  申请人：——

  公开号：US6903131B2

  公开（公告）日：2005-06-07