Chlor-dimethylamino-trifluormethyl-phosphin | 3135-63-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: Chlor-dimethylamino-trifluormethyl-phosphin
• 英文别名: Trifluormethyl-dimethylamino-chlorphosphin；Chlor--trifluormethyl-phosphin；Phosphonamidous chloride, N,N-dimethyl-P-(trifluoromethyl)-；N-[chloro(trifluoromethyl)phosphanyl]-N-methylmethanamine
• CAS: 3135-63-5
• 化学式: C₃H₆ClF₃NP
• 分子量: 179.509
• InChiKey: WTKYQWKIVWZVJF-UHFFFAOYSA-N

物化性质

• 沸点：
  83.6±45.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Chlor-dimethylamino-trifluormethyl-phosphin 、 保护胸苷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Studies on trifluoromethylphosphonamidite analogues as building blocks in oligonucleotide synthesis

  摘要：

  The phosphorylating reagents CF3P(NMe(2))Cl and CF3P(NEt(2))Cl are used to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites. Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.

  DOI：

  10.1016/0040-4039(95)00186-g
• 作为产物：
  描述：

  Bis---phosphin 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 Chlor-dimethylamino-trifluormethyl-phosphin
  参考文献：
  名称：

  Studies on trifluoromethylphosphonamidite analogues as building blocks in oligonucleotide synthesis

  摘要：

  The phosphorylating reagents CF3P(NMe(2))Cl and CF3P(NEt(2))Cl are used to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites. Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.

  DOI：

  10.1016/0040-4039(95)00186-g

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.3, 1.9, page 70 - 123
  作者：

  DOI：——

  日期：——
• Nixon, J. F.; Cavell, R. G., Journal of the Chemical Society
  作者：Nixon, J. F.、Cavell, R. G.

  DOI：——

  日期：——
• Phosphines Containing the CH₃CF₃P Group¹
  作者：Anton B. Burg、K. K. Joshi、John F. Nixon

  DOI：10.1021/ja00953a007

  日期：1966.1
• Studies on trifluoromethylphosphonamidite analogues as building blocks in oligonucleotide synthesis
  作者：Michael Mayer、Ivar Ugi、Wolfgang Richter

  DOI：10.1016/0040-4039(95)00186-g

  日期：1995.3

  The phosphorylating reagents CF3P(NMe(2))Cl and CF3P(NEt(2))Cl are used to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites. Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.