6,7-dimethoxy-2-methyl-quinazoline | 83675-03-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dimethoxy-2-methyl-quinazoline
• 英文别名: 6,7-Dimethoxy-2-methyl-chinazolin；6,7-Dimethoxy-2-methylchinazolin；6,7-Dimethoxy-2-methylquinazoline
• CAS: 83675-03-0
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: FQTFIMUPUQFJFK-UHFFFAOYSA-N

物化性质

• 熔点：
  165 °C
• 沸点：
  264.2±33.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3,4-dimethoxy-6-nitro-benzyliden)-aniline 在 sodium sulfide 、 乙醇 、 alkaline solution 、 氨 作用下， 生成 6,7-dimethoxy-2-methyl-quinazoline
  参考文献：
  名称：

  Rilliet, Helvetica Chimica Acta, 1922, vol. 5, p. 548

  摘要：

  DOI：

文献信息

• C-Met Modulators and Method of Use
  申请人：Bannen Lynne Canne

  公开号：US20110077233A1

  公开（公告）日：2011-03-31

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学侵袭）的化合物。更具体地，本发明提供了能够抑制、调节和/或调节激酶受体（特别是c-Met、KDF、c-Kit、flt-3和flt-4）信号转导通路的喹唑啉和喹啉，这些信号转导通路与上述细胞活动的变化有关，以及包含这些化合物的组合物和使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供了制备上述化合物的方法和包含这些化合物的组合物。
• SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20150072959A1

  公开（公告）日：2015-03-12

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本文揭示了替代三唑类化合物及含有该化合物的药物组合物，用于抑制受体蛋白酪氨酸激酶Axl的活性。还揭示了使用该化合物治疗与Axl活性相关的疾病或病状的方法。
• c-Met Modulators and Method of Use
  申请人：Exelixis, Inc.

  公开号：US20160185725A1

  公开（公告）日：2016-06-30

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了一种用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学侵袭）的化合物。更具体地，本发明提供了喹唑啉和喹啉，它们抑制、调节和/或调节激酶受体，特别是c-Met、KDF、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导通路，以及包含这些化合物的组合物和使用它们治疗激酶依赖性疾病和病症的方法。本发明还提供了制备上述化合物的方法和包含这些化合物的组合物。
• Lempert-Sreter, Magda; Lempert, Karoly; Moeller, Joergen, Journal of the Chemical Society. Perkin transactions I, 1984, # 6, p. 1143 - 1152
  作者：Lempert-Sreter, Magda、Lempert, Karoly、Moeller, Joergen

  DOI：——

  日期：——
• Substituted triazoles useful as AXL inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2476679B1

  公开（公告）日：2015-10-14