C8 beta-D-galactosyl N-acylsphingosine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: C8 beta-D-galactosyl N-acylsphingosine
• 英文别名: N-[(E,2S,3R)-3-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadec-4-en-2-yl]octanamide
• 化学式: C₃₂H₆₁NO₈
• 分子量: 587.838
• InChiKey: LCEXEEHGNKGJES-SWMJIITPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  41
• 可旋转键数：
  25
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  神经鞘氨醇半乳糖苷 、 辛酰氯 在 吡啶 作用下， 以 N-甲基吡咯烷酮 、 四氢呋喃 为溶剂， 生成 C8 beta-D-galactosyl N-acylsphingosine
  参考文献：
  名称：

  The Synthesis and Biological Characterization of a Ceramide Library

  摘要：

  A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.

  DOI：

  10.1021/ja017576o

文献信息

• Methods for detection of lysosomal storage disease
  申请人：Zhang Xiaokui K.

  公开号：US20080248513A1

  公开（公告）日：2008-10-09

  The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.

  本发明提供了用于执行与溶酶体贮积病相关的酶活性测定的组合物。该发明还提供了测定酶活性的方法，以及筛选个体的溶酶体贮积病的方法。
• US8431335B2
  申请人：——

  公开号：US8431335B2

  公开（公告）日：2013-04-30
• The Synthesis and Biological Characterization of a Ceramide Library
  作者：Young-Tae Chang、Jaehwa Choi、Sheng Ding、Eva E. Prieschl、Thomas Baumruker、Jae-Mok Lee、Sung-Kee Chung、Peter G. Schultz

  DOI：10.1021/ja017576o

  日期：2002.3.1

  A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.